AIMC Topic: Computer Simulation

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Neuroadaptive fixed-time fault-tolerant containment control of high-order MIMO Nonlinear multi-agent systems in affine strict-feedback form.

Neural networks : the official journal of the International Neural Network Society
This paper is concerned with the fixed-time containment control problem for high-order MIMO nonlinear multi-agent systems with external disturbances and actuator faults. First, in the backstepping framework, a neuroadaptive fixed-time containment con...

Implementing feature binding through dendritic networks of a single neuron.

Neural networks : the official journal of the International Neural Network Society
A single neuron receives an extensive array of synaptic inputs through its dendrites, raising the fundamental question of how these inputs undergo integration and summation, culminating in the initiation of spikes in the soma. Experimental and comput...

Physics-informed multi-output Gaussian process for dynamical system modeling.

Neural networks : the official journal of the International Neural Network Society
Learning accurate dynamics models is crucial for model-based reinforcement learning. Gaussian processes (GPs), as a probabilistic modeling approach, have been widely used for dynamical system modeling. However, standard GPs are designed for single-ou...

Robot-Mediated Asymmetric Connection Between Humans Can Improve Performance Without Increasing Effort.

IEEE transactions on bio-medical engineering
UNLABELLED: Whether working together to move a table or supporting a child learning to ride a bike, physically connected individuals exchange haptic information to improve motor performance. However, this improvement occurs at the cost of additional ...

Computational modelling of aggressive B-cell lymphoma.

Biochemical Society transactions
Decades of research into the molecular signalling determinants of B cell fates, and recent progress in characterising the genetic drivers of lymphoma, has led to a detailed understanding of B cell malignancies but also revealed daunting heterogeneity...

Comparing Deterministic and Stochastic Reinforcement Learning for Glucose Regulation in Type 1 Diabetes.

Studies in health technology and informatics
Type 1 Diabetes (T1D) is a chronic condition affecting millions worldwide, requiring external insulin administration to regulate blood glucose levels and prevent serious complications. Artificial Pancreas Systems (APS) for managing T1D currently rely...

In-silico evaluation of aging-related interventions using omics data and predictive modeling.

Ageing research reviews
A major challenge in aging research is identifying interventions that can improve lifespan and health and minimize toxicity. Clinical studies cannot usually consider decades-long follow-up periods, and therefore, in-silico evaluations using omics-bas...

In silico design strategies for tubulin inhibitors for the development of anticancer therapies.

Expert opinion on drug discovery
INTRODUCTION: Microtubules, composing of α, β-tubulin dimers, are important for cellular processes like proliferation and transport, thereby they become suitable targets for research in cancer. Existing candidates often exhibit off-target effects, ne...

Development of patient-specific apparent blood viscosity predictive models for computational fluid dynamics analysis of intracranial aneurysms with machine learning approaches.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVES: A model to predict patient-specific apparent viscosity as a computational condition in computational fluid dynamics (CFD) analysis, which is used in research on intracranial aneurysms, is important. The purpose of this stud...

Decoding virulence and resistance in Klebsiella pneumoniae: Pharmacological insights, immunological dynamics, and in silico therapeutic strategies.

Microbial pathogenesis
Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the leading members of ESKAPE pathogens, it plays a major role in a wide range of infections that cause ...