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Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects.

Nature communications
We present comboFM, a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells. comboFM models the cell context-specific drug interactions through...

Explainable artificial intelligence for precision medicine in acute myeloid leukemia.

Frontiers in immunology
Artificial intelligence (AI) can unveil novel personalized treatments based on drug screening and whole-exome sequencing experiments (WES). However, the concept of "black box" in AI limits the potential of this approach to be translated into the clin...