AIMC Topic: Bortezomib
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Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Acta pharmacologica Sinica
Feb 21, 2025
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...
Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects.
Nature communications
Dec 1, 2020
We present comboFM, a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells. comboFM models the cell context-specific drug interactions through...
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