AIMC Topic: Leukemia, Myeloid, Acute
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Unveiling the role of coagulation-related genes in acute myeloid leukemia prognosis and immune microenvironment through machine learning.
European journal of medical research
Aug 11, 2025
BACKGROUND: Acute Myeloid Leukemia (AML) is a highly heterogeneous hematologic malignancy influenced by various factors affecting prognosis. Recently, the role of coagulation-related genes in tumor biology has garnered increasing attention. This stud...
Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.
Nature communications
Jul 29, 2025
Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML.
Journal of translational medicine
Jul 24, 2025
BACKGROUND: Comprehensive analysis of single-cell transcriptome and chromatin accessibility will contribute to interpret the heterogeneity of acute myeloid leukemia (AML). We hypothesize that integrating single-cell transcriptomic and chromatin acces...
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.
Science advances
Jul 9, 2025
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.
Journal of translational medicine
May 21, 2025
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
Machine learning approaches reveal methylation signatures associated with pediatric acute myeloid leukemia recurrence.
Scientific reports
May 6, 2025
Acute myeloid leukemia (AML) is a severe hematological malignancy characterized by high recurrence rates, especially in pediatric patients, highlighting the need for reliable prognostic markers. This study proposes methylation signatures associated w...
Identification of relevant features using SEQENS to improve supervised machine learning models predicting AML treatment outcome.
BMC medical informatics and decision making
May 1, 2025
BACKGROUND AND OBJECTIVE: This study has two main objectives. First, to evaluate a feature selection methodology based on SEQENS, an algorithm for identifying relevant variables. Second, to validate machine learning models that predict the risk of co...
Integrated multiomics analysis and machine learning refine neutrophil extracellular trap-related molecular subtypes and prognostic models for acute myeloid leukemia.
Frontiers in immunology
Feb 24, 2025
BACKGROUND: Neutrophil extracellular traps (NETs) play pivotal roles in various pathological processes. The formation of NETs is impaired in acute myeloid leukemia (AML), which can result in immunodeficiency and increased susceptibility to infection.
Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia.
BMC cancer
Feb 15, 2025
BACKGROUND: Dysregulation or abnormality of the programmed cell death (PCD) pathway is closely related to the occurrence and development of many tumors, including acute myeloid leukemia (AML). Studying the abnormal characteristics of PCD pathway-rela...
Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DC mediated T-cell activation and on-target/off-tumor toxicity.
Frontiers in immunology
Jan 30, 2025
Acute myeloid leukemia (AML) remains a devastating diagnosis in clear need of therapeutic advances. Both targeted dendritic cells (DC) and particularly leukemia-derived dendritic cells (DC) can exert potent anti-leukemic activity. By converting AML b...
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