AIMC Topic: Cryoelectron Microscopy

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An Unsupervised Classification Algorithm for Heterogeneous Cryo-EM Projection Images Based on Autoencoders.

International journal of molecular sciences May 6, 2023
Heterogeneous three-dimensional (3D) reconstruction in single-particle cryo-electron microscopy (cryo-EM) is an important but very challenging technique for recovering the conformational heterogeneity of flexible biological macromolecules such as pro...
Single Molecule Imaging Neural Networks, Computer Cryoelectron Microscopy Algorithms Image Processing, Computer-Assisted Cluster Analysis
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Unsupervised Cryo-EM Images Denoising and Clustering Based on Deep Convolutional Autoencoder and K-Means+.

IEEE transactions on medical imaging May 2, 2023
Cryo-electron microscopy (cryo-EM) is a widely used structural determination technique. Because of the extremely low signal-to-noise ratio (SNR) of images captured by cryo-EM, clustering single-particle cryo-EM images with high accuracy is challengin...
Neural Networks, Computer Reproducibility of Results Signal-To-Noise Ratio Cryoelectron Microscopy Image Processing, Computer-Assisted Cluster Analysis
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Measuring cryo-TEM sample thickness using reflected light microscopy and machine learning.

Journal of structural biology Apr 24, 2023
In cryo-transmission electron microscopy (cryo-TEM), sample thickness is one of the most important parameters that governs image quality. When combining cryo-TEM with other imaging methods, such as light microscopy, measuring and controlling the samp...
Proteins Mammals Software Animals Microscopy, Electron, Transmission Cryoelectron Microscopy Machine Learning
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Top-down design of protein architectures with reinforcement learning.

Science (New York, N.Y.) Apr 20, 2023
As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approa...
Protein Engineering Cryoelectron Microscopy Nanostructures Machine Learning Proteins
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CryoRes: Local Resolution Estimation of Cryo-EM Density Maps by Deep Learning.

Journal of molecular biology Mar 24, 2023
Recent progress in cryo-EM research has ignited a revolution in biological macromolecule structure determination. Resolution is an essential parameter for quality assessment of a cryo-EM density map, and it is known that resolution varies in differen...
Algorithms Deep Learning Models, Molecular Cryoelectron Microscopy Macromolecular Substances Protein Conformation
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Cryo-electron Microscopy Reveals the Structure of the Nuclear Pore Complex.

Journal of molecular biology Mar 17, 2023
The nuclear pore complex (NPC) is a giant protein assembly that penetrates the double layers of the nuclear membrane. The overall structure of the NPC has approximately eightfold symmetry and is formed by approximately 30 nucleoporins. The great size...
Cryoelectron Microscopy Nuclear Pore Complex Proteins Nuclear Envelope Nuclear Pore Artificial Intelligence
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Applications and prospects of cryo-EM in drug discovery.

Military Medical Research Mar 6, 2023
Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology has been demonstrated as a powerful tool to...
Drug Discovery Cryoelectron Microscopy Proteolysis Targeting Chimera Artificial Intelligence Quality of Life Humans
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Integrating Molecular Models Into CryoEM Heterogeneity Analysis Using Scalable High-resolution Deep Gaussian Mixture Models.

Journal of molecular biology Feb 16, 2023
Resolving the structural variability of proteins is often key to understanding the structure-function relationship of those macromolecular machines. Single particle analysis using Cryogenic electron microscopy (CryoEM), combined with machine learning...
Algorithms Models, Molecular Neural Networks, Computer Microscopy, Electron Cryoelectron Microscopy
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Deep learning for reconstructing protein structures from cryo-EM density maps: Recent advances and future directions.

Current opinion in structural biology Feb 9, 2023
Cryo-Electron Microscopy (cryo-EM) has emerged as a key technology to determine the structure of proteins, particularly large protein complexes and assemblies in recent years. A key challenge in cryo-EM data analysis is to automatically reconstruct a...
Cryoelectron Microscopy Amino Acid Sequence Protein Conformation Models, Molecular Deep Learning Proteins
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Smart de novo Macromolecular Structure Modeling from Cryo-EM Maps.

Journal of molecular biology Jan 18, 2023
The study of macromolecular structures has expanded our understanding of the amazing cell machinery and such knowledge has changed how the pharmaceutical industry develops new vaccines in recent years. Traditionally, X-ray crystallography has been th...
Models, Molecular Macromolecular Substances Protein Conformation Cryoelectron Microscopy Software Artificial Intelligence Proteins
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