AIMC Topic: Cytidine

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TransCNN: A novel architecture combining transformer and TextCNN for detecting N4-acetylcytidine sites in human mRNA.

Analytical biochemistry Apr 29, 2025
N4-acetylcytidine (ac4C), a pivotal post-transcriptional RNA modification, is central to understanding transcriptional regulation and diverse biological processes. As a key determinant of RNA structural stability and functional regulation, ac4C has b...
Humans Cytidine RNA Processing, Post-Transcriptional RNA, Messenger Neural Networks, Computer
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ERNIE-ac4C: A Novel Deep Learning Model for Effectively Predicting N4-acetylcytidine Sites.

Journal of molecular biology Feb 1, 2025
RNA modifications are known to play a critical role in gene regulation and cellular processes. Specifically, N4-acetylcytidine (ac4C) modification has emerged as a significant marker involved in mRNA translation efficiency, stability, and various dis...
RNA Processing, Post-Transcriptional Cytidine Deep Learning Neural Networks, Computer RNA Computational Biology Humans
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Caps-ac4C: An effective computational framework for identifying N4-acetylcytidine sites in human mRNA based on deep learning.

Journal of molecular biology Jan 28, 2025
N4-acetylcytidine (ac4C) is a crucial post-transcriptional modification in human mRNA, involving the acetylation of the nitrogen atom at the fourth position of cytidine. This modification, catalyzed by N-acetyltransferases such as NAT10, is primarily...
Computational Biology RNA, Messenger Deep Learning Humans RNA Processing, Post-Transcriptional Cytidine
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TransC-ac4C: Identification of N4-Acetylcytidine (ac4C) Sites in mRNA Using Deep Learning.

IEEE/ACM transactions on computational biology and bioinformatics Oct 9, 2024
N4-acetylcytidine (ac4C) is a post-transcriptional modification in mRNA that is critical in mRNA translation in terms of stability and regulation. In the past few years, numerous approaches employing convolutional neural networks (CNN) and Transforme...
Cytidine RNA, Messenger Sequence Analysis, RNA Computational Biology Algorithms Deep Learning
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GANSamples-ac4C: Enhancing ac4C site prediction via generative adversarial networks and transfer learning.

Analytical biochemistry Feb 29, 2024
RNA modification, N4-acetylcytidine (ac4C), is enzymatically catalyzed by N-acetyltransferase 10 (NAT10) and plays an essential role across tRNA, rRNA, and mRNA. It influences various cellular functions, including mRNA stability and rRNA biosynthesis...
RNA Stability Machine Learning Cytidine RNA
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MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks.

Genomics Nov 25, 2023
MOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory...
RNA Deep Learning Cytidine
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LSA-ac4C: A hybrid neural network incorporating double-layer LSTM and self-attention mechanism for the prediction of N4-acetylcytidine sites in human mRNA.

International journal of biological macromolecules Sep 13, 2023
N4-acetylcytidine (ac4C) is a vital constituent of the epitranscriptome and plays a crucial role in the regulation of mRNA expression. Numerous studies have established correlations between ac4C and the incidence, progression and prognosis of various...
Cytidine RNA, Messenger Neural Networks, Computer Machine Learning Humans
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Benzoyl Chloride Derivatization Coupled With Liquid Chromatography-Mass Spectrometry for the Simultaneous Quantification of Molnupiravir and Its Metabolite β-d-N-hydroxycytidine in Human Plasma.

Journal of separation science May 1, 2025
A sensitive and efficient method for simultaneous quantifying molnupiravir and its active metabolite β-d-N-hydroxycytidine in human plasma was developed by combining chemical derivatization with liquid chromatography-tandem mass spectrometry. Through...
Molecular Structure Hydroxylamines Cytidine Chromatography, Liquid Humans Liquid Chromatography-Mass Spectrometry Chromatography, High Pressure Liquid Tandem Mass Spectrometry
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DPNN-ac4C: a dual-path neural network with self-attention mechanism for identification of N4-acetylcytidine (ac4C) in mRNA.

Bioinformatics (Oxford, England) Nov 1, 2024
MOTIVATION: The modification of N4-acetylcytidine (ac4C) in RNA is a conserved epigenetic mark that plays a crucial role in post-transcriptional regulation, mRNA stability, and translation efficiency. Traditional methods for detecting ac4C modificati...
RNA, Messenger Cytidine Computational Biology Algorithms Neural Networks, Computer
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Detection of Ningnanmycin Using Fluorescence Spectroscopy Combined with BP Neural Network.

Combinatorial chemistry & high throughput screening Jan 1, 2023
BACKGROUND: Ningnanmycin is a new antibiotic pesticide with good bactericidal and antiviral efficacy, which is widely used in the control of fruit and vegetable diseases, and the excessive pesticide residues pose a serious threat to the environment a...
Humans Fruit Spectrometry, Fluorescence Cytidine Neural Networks, Computer
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