AIMC Topic: RNA Stability
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Deciphering disordered regions controlling mRNA decay in high-throughput.
Nature
Apr 23, 2025
Intrinsically disordered regions within proteins drive specific molecular functions despite lacking a defined structure. Although disordered regions are integral to controlling mRNA stability and translation, the mechanisms underlying these regulator...
Predicting synthetic mRNA stability using massively parallel kinetic measurements, biophysical modeling, and machine learning.
Nature communications
Nov 6, 2024
mRNA degradation is a central process that affects all gene expression levels, though it remains challenging to predict the stability of a mRNA from its sequence, due to the many coupled interactions that control degradation rate. Here, we carried ou...
GANSamples-ac4C: Enhancing ac4C site prediction via generative adversarial networks and transfer learning.
Analytical biochemistry
Feb 29, 2024
RNA modification, N4-acetylcytidine (ac4C), is enzymatically catalyzed by N-acetyltransferase 10 (NAT10) and plays an essential role across tRNA, rRNA, and mRNA. It influences various cellular functions, including mRNA stability and rRNA biosynthesis...
RNAdegformer: accurate prediction of mRNA degradation at nucleotide resolution with deep learning.
Briefings in bioinformatics
Jan 19, 2023
Messenger RNA-based therapeutics have shown tremendous potential, as demonstrated by the rapid development of messenger RNA based vaccines for COVID-19. Nevertheless, distribution of mRNA vaccines worldwide has been hampered by mRNA's inherent therma...
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