AIMC Topic: Daptomycin

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A Machine Learning Algorithm to Predict the Starting Dose of Daptomycin.

Clinical pharmacokinetics Jul 31, 2024
BACKGROUND AND OBJECTIVE: The dosage of daptomycin is usually based on body weight. However, it has been shown that this approach yields too high an exposure in obese patients. Pharmacokinetic and pharmacodynamic indexes (PK/PD) have been proposed fo...
Humans Machine Learning Algorithms Anti-Bacterial Agents Computer Simulation Female Aged Adult Male Middle Aged Dose-Response Relationship, Drug Area Under Curve Models, Biological Body Weight Monte Carlo Method Daptomycin
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A machine learning approach to predict daptomycin exposure from two concentrations based on Monte Carlo simulations.

Antimicrobial agents and chemotherapy Mar 19, 2024
Daptomycin is a concentration-dependent lipopeptide antibiotic for which exposure/effect relationships have been shown. Machine learning (ML) algorithms, developed to predict the individual exposure to drugs, have shown very good performances in comp...
Humans Machine Learning Algorithms Anti-Bacterial Agents Female Aged Adult Male Middle Aged Area Under Curve Bayes Theorem Monte Carlo Method Daptomycin
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