AIMC Topic: Decitabine

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Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.

Science advances Jul 9, 2025
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
Humans Tumor Microenvironment Leukemia, Myeloid, Acute Gene Expression Profiling Transcriptome Single-Cell Analysis Immunotherapy Antibodies, Monoclonal, Humanized Bone Marrow Decitabine
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Computational simulation and target prediction studies of solubility optimization of decitabine through supercritical solvent.

Scientific reports Nov 7, 2022
Computational analysis of drug solubility was carried out using machine learning approach. The solubility of Decitabine as model drug in supercritical CO was studied as function of pressure and temperature to assess the feasibility of that for produc...
Machine Learning Computer Simulation Solubility Solvents Decitabine
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Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug.

Molecules (Basel, Switzerland) Sep 2, 2022
The efficient production of solid-dosage oral formulations using eco-friendly supercritical solvents is known as a breakthrough technology towards developing cost-effective therapeutic drugs. Drug solubility is a significant parameter which must be m...
Humans Artificial Intelligence Antineoplastic Agents Models, Theoretical Solubility Decitabine
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