DNA-binding proteins play a vital role in biological activity including DNA replication, DNA packing, and DNA reparation. DNA-binding proteins can be classified into single-stranded DNA-binding proteins (SSBs) or double-stranded DNA-binding proteins ...
DNA-binding proteins actively participate in life activities such as DNA replication, recombination, gene expression and regulation and play a prominent role in these processes. As DNA-binding proteins continue to be discovered and increase, it is im...
Accurate prediction of DNA-protein binding (DPB) is of great biological significance for studying the regulatory mechanism of gene expression. In recent years, with the rapid development of deep learning techniques, advanced deep neural networks have...
Proteins interact with nucleic acids to regulate the life activities of organisms. Therefore, how to accurately and efficiently identify nucleic acid-binding proteins (NABPs) is particularly significant. Some sequence-based computational methods have...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs) are two important nucleic acid-binding proteins (NABPs), which play important roles in biological processes such as replication, translation and transcription of genetic material. Some prote...
Computational and mathematical methods in medicine
Jun 2, 2022
Protein is closely related to life activities. As a kind of protein, DNA-binding protein plays an irreplaceable role in life activities. Therefore, it is very important to study DNA-binding protein, which is a subject worthy of study. Although tradit...
Accurate identification of DNA-binding proteins (DBPs) is critical for both understanding protein function and drug design. DBPs also play essential roles in different kinds of biological activities such as DNA replication, repair, transcription, and...
DNA contains the genetic information for the synthesis of proteins and RNA, and it is an indispensable substance in living organisms. DNA-binding proteins are an enzyme, which can bind with DNA to produce complex proteins, and play an important role ...
Interdisciplinary sciences, computational life sciences
Nov 6, 2021
Due to the high cost of DNA-binding proteins (DBPs) detection, many machine learning algorithms (ML) have been utilized to large-scale process and detect DBPs. The previous methods took no count of the processing of noise samples. In this study, a fu...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2021
Discovering DNA-protein binding sites, also known as motif discovery, is the foundation for further analysis of transcription factors (TFs). Deep learning algorithms such as convolutional neural networks (CNN) have been introduced to motif discovery ...
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