AIMC Topic: DNA-Directed DNA Polymerase
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Coordinated Residue Motions at the Enzyme-Substrate Interface Promote DNA Translocation in Polymerases.
Journal of the American Chemical Society
Jun 17, 2025
The translocation of DNA in polymerase (Pol) enzymes is a critical step for Pol-mediated nucleic acid polymerization, essential for storing and transmitting genetic information in all living organisms. During this process, the newly elongated double-...
Prediction of African Swine Fever Virus Inhibitors by Molecular Docking-Driven Machine Learning Models.
Molecules (Basel, Switzerland)
Jun 11, 2021
African swine fever virus (ASFV) causes a highly contagious and severe hemorrhagic viral disease with high mortality in domestic pigs of all ages. Although the virus is harmless to humans, the ongoing ASFV epidemic could have severe economic conseque...
Rapid Rule Out of Culture-Negative Bloodstream Infections by Use of a Novel Approach to Universal Detection of Bacteria and Fungi.
The journal of applied laboratory medicine
Nov 20, 2018
BACKGROUND: Currently it can take up to 5 days to rule out bloodstream infection. With the low yield of blood cultures (approximately 10%), a significant number of patients are potentially exposed to inappropriate therapy that can lead to adverse eve...
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