AIMC Topic: Drug Development

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ChatGPT or LLM in next-generation drug discovery and development: pharmaceutical and biotechnology companies can make use of the artificial intelligence-based device for a faster way of drug discovery and development.

International journal of surgery (London, England) Dec 1, 2023
Humans Artificial Intelligence Drug Industry Biotechnology Drug Development Drug Discovery
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VGAE-MCTS: A New Molecular Generative Model Combining the Variational Graph Auto-Encoder and Monte Carlo Tree Search.

Journal of chemical information and modeling Nov 22, 2023
Molecular generation is crucial for advancing drug discovery, materials science, and chemical exploration. It expedites the search for new drug candidates, facilitates tailored material creation, and enhances our understanding of molecular diversity....
Learning Monte Carlo Method Drug Development Drug Discovery Artificial Intelligence
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EGeRepDR: An enhanced genetic-based representation learning for drug repurposing using multiple biomedical sources.

Journal of biomedical informatics Oct 18, 2023
MOTIVATION: Drug repurposing (DR) is an imminent approach for identifying novel therapeutic indications for the available drugs and discovering novel drugs for previously untreatable diseases. Nowadays, DR has major attention in the pharmaceutical in...
Drug Development Drug Repositioning Learning Neural Networks, Computer
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Artificial intelligence for dementia prevention.

Alzheimer's & dementia : the journal of the Alzheimer's Association Oct 14, 2023
INTRODUCTION: A wide range of modifiable risk factors for dementia have been identified. Considerable debate remains about these risk factors, possible interactions between them or with genetic risk, and causality, and how they can help in clinical t...
Machine Learning Risk Factors Artificial Intelligence Humans Drug Development Dementia
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Artificial intelligence in small molecule drug discovery from 2018 to 2023: Does it really work?

Bioorganic chemistry Sep 27, 2023
Utilizing artificial intelligence (AI) in drug design represents an advanced approach for identifying targets and developing new drugs. Integrating AI techniques significantly reduces the workload involved in drug development and enhances the efficie...
Artificial Intelligence Drug Development Drug Discovery Drug Design
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Deep learning driven de novo drug design based on gastric proton pump structures.

Communications biology Sep 19, 2023
Existing drugs often suffer in their effectiveness due to detrimental side effects, low binding affinity or pharmacokinetic problems. This may be overcome by the development of distinct compounds. Here, we exploit the rich structural basis of drug-bo...
Stomach Drug Development Drug Design Deep Learning Pharmacophore
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Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges.

Drug development research Sep 15, 2023
By harnessing artificial intelligence (AI) algorithms and machine learning techniques, the entire drug discovery process stands to undergo a profound transformation, offering a myriad of advantages. Foremost among these is the ability of AI to conduc...
Artificial Intelligence Drug Discovery Drug Development Machine Learning
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DAHNGC: A Graph Convolution Model for Drug-Disease Association Prediction by Using Heterogeneous Network.

Journal of computational biology : a journal of computational molecular cell biology Sep 13, 2023
In the field of drug development and repositioning, the prediction of drug-disease associations is a critical task. A recently proposed method for predicting drug-disease associations based on graph convolution relies heavily on the features of adjac...
Neural Networks, Computer Drug Development
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FDA Modernization Act 2.0: An insight from nondeveloping country.

Drug development research Aug 17, 2023
Animal testing is required in drug development research and is crucial for assessing the efficacy and safety of medications before they are commercialized. However, the newly furnished Food and Drug Administration Modernization Act 2.0 has given new ...
Humans Artificial Intelligence United States Drug Development United States Food and Drug Administration Animals Pharmaceutical Preparations Drug Approval
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Organ-on-a-chip meets artificial intelligence in drug evaluation.

Theranostics Aug 15, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation. Organ-on-...
Microphysiological Systems Animals Humans Artificial Intelligence Reproducibility of Results Drug Development Drug Evaluation
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