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Microphysiological Systems

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Neural network execution using nicked DNA and microfluidics.

PloS one
DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media. However, ...

Organ-on-a-chip meets artificial intelligence in drug evaluation.

Theranostics
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation. Organ-on-...

The Synergy between Deep Learning and Organs-on-Chips for High-Throughput Drug Screening: A Review.

Biosensors
Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a class of advanced in vitro models. Deep learning, as an emerging topic in machine learning, has the ability to extract a hidden statistical relationship from the in...

Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning.

Annals of biomedical engineering
Vascularized microphysiological systems and organoids are contemporary preclinical experimental platforms representing human tissue or organ function in health and disease. While vascularization is emerging as a necessary physiological organ-level fe...

Genetic algorithm-based optimal design for fluidic artificial muscle (FAM) bundles.

Bioinspiration & biomimetics
In this paper, we present a design optimization framework for a fluidic artificial muscle (FAM) bundle subject to geometric constraints. The architecture of natural skeletal muscles allows for compact actuation packaging by distributing a substantial...