AIMC Topic: Microphysiological Systems

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Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer.

Journal of translational medicine Jul 16, 2025
BACKGROUND: Head and neck cancer (HNC) presents significant research challenges due to the complexity of its tumor microenvironment (TME) and the heterogeneity across different cancer subtypes. Recent advancements in three-dimensional (3D) culture mo...
Humans Tumor Microenvironment Animals Head and Neck Neoplasms Carcinogenesis Lab-On-A-Chip Devices Spheroids, Cellular Organoids Microphysiological Systems
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Genetic algorithm-based optimal design for fluidic artificial muscle (FAM) bundles.

Bioinspiration & biomimetics Dec 3, 2024
In this paper, we present a design optimization framework for a fluidic artificial muscle (FAM) bundle subject to geometric constraints. The architecture of natural skeletal muscles allows for compact actuation packaging by distributing a substantial...
Algorithms Muscle, Skeletal Robotics Muscle Contraction Microphysiological Systems
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Neural network execution using nicked DNA and microfluidics.

PloS one Oct 19, 2023
DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media. However, ...
Neural Networks, Computer DNA Microfluidics Lab-On-A-Chip Devices Microphysiological Systems
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Organ-on-a-chip meets artificial intelligence in drug evaluation.

Theranostics Aug 15, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation. Organ-on-...
Humans Artificial Intelligence Reproducibility of Results Animals Drug Development Drug Evaluation Microphysiological Systems
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The Synergy between Deep Learning and Organs-on-Chips for High-Throughput Drug Screening: A Review.

Biosensors Mar 15, 2023
Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a class of advanced in vitro models. Deep learning, as an emerging topic in machine learning, has the ability to extract a hidden statistical relationship from the in...
Humans Deep Learning Drug Evaluation, Preclinical Microfluidics High-Throughput Screening Assays Microphysiological Systems
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Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning.

Annals of biomedical engineering Mar 13, 2023
Vascularized microphysiological systems and organoids are contemporary preclinical experimental platforms representing human tissue or organ function in health and disease. While vascularization is emerging as a necessary physiological organ-level fe...
Humans Neural Networks, Computer Machine Learning Oxygen Supervised Machine Learning Microphysiological Systems
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