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Drug Evaluation

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Searches for randomized controlled trials of drugs in MEDLINE and EMBASE using only generic drug names compared with searches applied in current practice in systematic reviews.

Research synthesis methods
BACKGROUND: It is unclear which terms should be included in bibliographic searches for randomized controlled trials (RCTs) of drugs, and identifying relevant drug terms can be extremely laborious. The aim of our analysis was to determine whether a bi...

Learning disease relationships from clinical drug trials.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Our objective is to test the limits of the assumption that better learning from data in medicine requires more granular data. We hypothesize that clinical trial metadata contains latent scientific, clinical, and regulatory expert knowledge...

Construction and Drug Evaluation Based on Convolutional Neural Network System Optimized by Grey Correlation Analysis.

Computational intelligence and neuroscience
Incidence rate of mental illness is increasing year by year with the development of city. The amount of modern medical data is huge and complex. In many cases, it is difficult to realize the rational allocation of resources, which puts forward an urg...

Flexibility in Drug Product Development: A Perspective.

Molecular pharmaceutics
The process of bringing a drug to market involves innumerable decisions to refine a concept into a final product. The final product goes through extensive research and development to meet the target product profile and to obtain a product that is man...

Artificial intelligence-enhanced drug design and development: Toward a computational precision medicine.

Drug discovery today
Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies with life science technologies to capture the value of massive multi-modal data in the form of predictive models supporting decision-making. AI and machine ...

Organ-on-a-chip meets artificial intelligence in drug evaluation.

Theranostics
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation. Organ-on-...

Human Motor System-Based Biohybrid Robot-On-a-Chip for Drug Evaluation of Neurodegenerative Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Biohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system. In addition, ...