AIMC Topic: Fanconi Anemia

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Prediction of myeloid malignant cells in Fanconi anemia using machine learning.

PloS one
Fanconi anemia (FA) is an inherited bone marrow failure syndrome with cancer predisposition. Most FA patients develop aplastic anemia during childhood and have an extremely high cumulative risk to develop cancer during their lifespan. Myeloid maligna...

Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models.

BMC bioinformatics
BACKGROUND: In spite of the abundance of genomic data, predictive models that describe phenotypes as a function of gene expression or mutations are difficult to obtain because they are affected by the curse of dimensionality, given the disbalance bet...