AIMC Topic: Fatty Liver

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An Ensemble Multilabel Classification for Disease Risk Prediction.

Journal of healthcare engineering
It is important to identify and prevent disease risk as early as possible through regular physical examinations. We formulate the disease risk prediction into a multilabel classification problem. A novel Ensemble Label Power-set Pruned datasets Joint...

Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.

Gut microbes
Alterations in the gut microbiome affect the development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH). We analyzed microbiomes of obese children with and w...

Machine Learning-Based Biomarker Identification for Early Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease.

The Journal of clinical endocrinology and metabolism
CONTEXT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an umbrella term for simple hepatic steatosis and the more severe metabolic dysfunction-associated steatohepatitis. The current reliance on liver biopsy for diagnosis and a ...

Downregulation of HDAC9 Alleviates Autophagy Dysfunction by Inducing Acetylation of ATG4B in Metabolic Dysfunction-Associated Steatotic Liver Disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic metabolic disorder with a rising global incidence. Epigenetic modifications-such as methylation, acetylation, phosphorylation, and ubiquitination-play critical ro...

Development of AI Based Fibrosis Detection Algorithm by SHG/TPEF Microscopy for Fully Quantified Liver Fibrosis Assessment in MASH.

Liver international : official journal of the International Association for the Study of the Liver
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global cause of chronic liver disease, with the potential to progress from steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrh...

Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice.

Toxicology and applied pharmacology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a spectrum of chronic pathologic conditions strongly associated with metabolic syndrome and affects approximately 38 % of the global population. Untreated MASLD may progress to metab...

CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...

Prediction Model for Insulin Resistance and Implications for MASLD in Youth: A Novel Marker, the Pediatric Insulin Resistance Assessment Score.

Yonsei medical journal
PURPOSE: Insulin resistance (IR) is a condition closely associated with cardiovascular risk factors and metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a significant IR-related complication. We aimed to develop a predi...