AIMC Topic: HIV Envelope Protein gp120

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RAIN: machine learning-based identification for HIV-1 bNAbs.

Nature communications Jun 24, 2024
Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance, automatic detection of HIV-1 bNAbs from immune repertoires is still lacking. Here, we develop a ...
HIV Envelope Protein gp120 CD4 Antigens Amino Acid Sequence HIV-1 Cryoelectron Microscopy HIV Antibodies HIV Infections Humans Antibodies, Neutralizing Machine Learning
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Application of deep learning and molecular modeling to identify small drug-like compounds as potential HIV-1 entry inhibitors.

Journal of biomolecular structure & dynamics Apr 15, 2021
A generative adversarial autoencoder for the rational design of potential HIV-1 entry inhibitors able to block CD4-binding site of the viral envelope protein gp120 was developed. To do this, the following studies were carried out: (i) an autoencoder ...
Molecular Docking Simulation Molecular Dynamics Simulation HIV-1 HIV Envelope Protein gp120 Deep Learning Anti-HIV Agents
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Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning.

Japanese journal of infectious diseases Jan 31, 2020
The monoclonal antibody 1C10 targets the V3 loop of HIV-1 and neutralizes a broad range of clade B viruses. However, the mode of interaction between 1C10 and the V3 loop remains unclear because crystallization of 1C10 and the V3 peptide was unsuccess...
Binding Sites, Antibody HIV Antibodies HIV Envelope Protein gp120 Peptide Fragments Antibodies, Neutralizing Amino Acid Sequence Amino Acid Substitution Deep Learning Antibodies, Monoclonal Humans Molecular Docking Simulation
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A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology Dec 20, 2016
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 corecepto...
Humans HIV Infections Decision Support Systems, Clinical Genotype CCR5 Receptor Antagonists HIV-2 Peptide Fragments Genotyping Techniques Internet Support Vector Machine HIV Envelope Protein gp120 Receptors, CCR5 Receptors, CXCR4
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Learning the Relationship between the Primary Structure of HIV Envelope Glycoproteins and Neutralization Activity of Particular Antibodies by Using Artificial Neural Networks.

International journal of molecular sciences Oct 11, 2016
The dependency between the primary structure of HIV envelope glycoproteins (ENV) and the neutralization data for given antibodies is very complicated and depends on a large number of factors, such as the binding affinity of a given antibody for a giv...
Magnetic Resonance Spectroscopy Neural Networks, Computer HIV Envelope Protein gp120 HIV Infections Inhibitory Concentration 50 Humans Crystallography, X-Ray Antibodies, Neutralizing Databases, Protein HIV-1 Models, Molecular
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AI-based IsAb2.0 for antibody design.

Briefings in bioinformatics Jul 25, 2024
Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, cu...
Humans Artificial Intelligence Single-Domain Antibodies Protein Engineering HIV Envelope Protein gp120 Computer Simulation Drug Design
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Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Aug 1, 2016
HIV-1 vaccine injection has been shown less effective due to the diversity of antigens. Increasing the knowledge of the associations between immune system and virus would ultimately result in producing effective vaccines against HIV-1 virus. To incre...
HIV Envelope Protein gp120 Unsupervised Machine Learning HIV-1 AIDS Vaccines Humans Killer Cells, Natural HIV Antibodies HIV Infections Models, Immunological
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