AIMC Topic: CCR5 Receptor Antagonists

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Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy.

HIV research & clinical practice Feb 4, 2020
Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interaction...
Humans Macrophages Biomarkers Female Male Middle Aged HIV Infections Anti-HIV Agents Cohort Studies Monocytes Inflammation Imidazoles CCR5 Receptor Antagonists Receptors, CCR2 Sulfoxides
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A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology Dec 20, 2016
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 corecepto...
Humans HIV Infections Decision Support Systems, Clinical Genotype Support Vector Machine Receptors, CXCR4 Peptide Fragments Internet CCR5 Receptor Antagonists Genotyping Techniques HIV Envelope Protein gp120 HIV-2 Receptors, CCR5
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