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Receptors, CCR5

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A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology 27998283
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 corecepto...
CCR5 Receptor Antagonists Decision Support Systems, Clinical Genotype Genotyping Techniques HIV Envelope Protein gp120 HIV Infections HIV-2 Humans Internet Peptide Fragments Receptors, CCR5 Receptors, CXCR4 Support Vector Machine
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Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning.

Frontiers in immunology 34262570
Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands across the immunologic spectrum of CO...
Algorithms Antibodies, Viral Case-Control Studies CD8-Positive T-Lymphocytes Chemokine CCL5 Computational Biology COVID-19 Female Humans Lymphocyte Activation Machine Learning Male Post-Acute COVID-19 Syndrome Prognosis Receptors, CCR5 RNA, Viral SARS-CoV-2 Severity of Illness Index T-Lymphocytes, Regulatory
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Analysis and validation of hub genes for atherosclerosis and AIDS and immune infiltration characteristics based on bioinformatics and machine learning.

Scientific reports 40210656
Atherosclerosis is the major cause of cardiovascular diseases worldwide, and AIDS linked with chronic inflammation and immune activation, increases atherosclerosis risk. The application of bioinformatics and machine learning to identify hub genes for...
Acquired Immunodeficiency Syndrome Atherosclerosis Computational Biology Databases, Genetic Gene Expression Profiling Gene Regulatory Networks Humans Machine Learning Protein Interaction Maps Receptors, CCR5 Transcriptome
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