AIMC Topic: Linkage Disequilibrium

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TAGOOS: genome-wide supervised learning of non-coding loci associated to complex phenotypes.

Nucleic acids research
Genome-wide association studies (GWAS) associate single nucleotide polymorphisms (SNPs) to complex phenotypes. Most human SNPs fall in non-coding regions and are likely regulatory SNPs, but linkage disequilibrium (LD) blocks make it difficult to dist...

The drug target genes show higher evolutionary conservation than non-target genes.

Oncotarget
Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing evolutionary features of drug targets from an overall level. Therefore, we conducted an analysis which aimed to investig...