AIMC Topic: Lipoxygenase

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Machine learning for target discovery in drug development.

Current opinion in chemical biology Nov 14, 2019
The discovery of macromolecular targets for bioactive agents is currently a bottleneck for the informed design of chemical probes and drug leads. Typically, activity profiling against genetically manipulated cell lines or chemical proteomics is pursu...
Humans Machine Learning Computer Simulation Antineoplastic Agents Proteomics Drug Evaluation, Preclinical Sesquiterpenes Molecular Targeted Therapy Transient Receptor Potential Channels Lipoxygenase Naphthoquinones Pentacyclic Triterpenes Receptors, Cannabinoid Sesquiterpenes, Guaiane
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Specialized oxygenated heterocyclics from Villorita cyprinoides with cyclooxygenase-2 and 5-lipoxygenase inhibitory properties.

Food research international (Ottawa, Ont.) Dec 28, 2017
Villorita cyprinoides is traditional seafood in the coastal regions of Arabian Sea. Bioactivity-guided purification of ethyl acetate:methanol extract of V. cyprinoides resulted in the identification of two O-spirocyclic ether derivatives (1-2) along ...
Humans Animals Molecular Docking Simulation Antioxidants Biological Products Structure-Activity Relationship Molecular Structure Oxygen Bivalvia Seafood Cyclooxygenase 2 Inhibitors Arachidonate 5-Lipoxygenase Cyclooxygenase 2 Lipoxygenase Lipoxygenase Inhibitors
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