Drug Target Interactions (DTIs) are crucial in drug discovery as it reduces the range of candidate searches, speeding up the drug screening process. Considering in vitro and in vivo experimentations are time and cost-expensive, there has been a surge...
Current opinion in structural biology
Feb 10, 2023
The factors determining a drug's success are manifold, making de novo drug design an inherently multi-objective optimisation (MOO) problem. With the advent of machine learning and optimisation methods, the field of multi-objective compound design has...
The identification of gene-disease associations plays an important role in the exploration of pathogenic mechanisms and therapeutic targets. Computational methods have been regarded as an effective way to discover the potential gene-disease associati...
BACKGROUND: Natural Language Processing (NLP) is widely used to extract clinical insights from Electronic Health Records (EHRs). However, the lack of annotated data, automated tools, and other challenges hinder the full utilisation of NLP for EHRs. V...
BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Active health screening for CRC yielded detection of an increasingly younger adults. However, current machine learning algorithms that are trained using older ...
INTRODUCTION: The effectiveness of rotator cuff tear repair surgery is influenced by multiple patient-related, pathology-centred and technical factors, which is thought to contribute to the reported retear rates between 17% and 94%. Adequate patient ...
Journal of bioinformatics and computational biology
Feb 10, 2023
This work proposes a machine learning-based phylogenetic tree generation model based on agglomerative clustering (PTGAC) that compares protein sequences considering all known chemical properties of amino acids. The proposed model can serve as a suita...
The Journal of hand surgery, European volume
Feb 9, 2023
Artificial intelligence (AI) in hand surgery is an emerging and evolving field that will likely play a large role in the future care of our patients. However, there remain several challenges to makes this technology meaningful, acceptable and usable ...
Neural networks : the official journal of the International Neural Network Society
Feb 9, 2023
This paper presents a computationally feasible method to compute rigorous bounds on the interval-generalization of regression analysis to account for epistemic uncertainty in the output variables. The new iterative method uses machine learning algori...
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