AIMC Topic: Mutagenesis, Site-Directed

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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Humans Animals Molecular Docking Simulation Cattle Computational Biology Models, Molecular Iodine Radioisotopes Expert Systems Biocatalysis Protein Conformation Cysteine Ubiquitin-Protein Ligases Amino Acid Substitution Recombinant Fusion Proteins Binding Sites Mutagenesis, Site-Directed Ubiquitin Ubiquitination Protein Multimerization Isoenzymes Point Mutation Ubiquitin-Conjugating Enzymes
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