AIMC Topic: Ubiquitin-Conjugating Enzymes

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UBE2D1 as a key biomarker in systemic juvenile idiopathic arthritis: a new perspective on diagnosis and disease activity assessment.

Arthritis research & therapy Jul 9, 2025
BACKGROUND: Early diagnosis is crucial for reducing disability and improving long-term prognosis in patients with systemic Juvenile Idiopathic Arthritis (sJIA), but it remains a significant challenge. This study aims to identify non-invasive biomarke...
Male Adolescent Biomarkers Female Monocytes Arthritis, Juvenile Ubiquitin-Conjugating Enzymes Child, Preschool Child Humans
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Identification and Validation of Glycosylation‑Related Genes in Ischemic Stroke Based on Bioinformatics and Machine Learning.

Journal of molecular neuroscience : MN Apr 29, 2025
Ischemic stroke (IS) constitutes a severe neurological disorder with restricted treatment alternatives. Recent investigations have disclosed that glycosylation is closely associated with the occurrence and outcome of IS. Nevertheless, data on the tra...
Humans Glycosylation Ischemic Stroke Ubiquitin-Conjugating Enzymes Gene Regulatory Networks Machine Learning Computational Biology Transcriptome
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Identification of UBE2N as a biomarker of Alzheimer's disease by combining WGCNA with machine learning algorithms.

Scientific reports Feb 22, 2025
Alzheimer's disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its ...
Gene Regulatory Networks Mice Animals Gene Expression Profiling Ubiquitin-Conjugating Enzymes Alzheimer Disease Hippocampus Humans Machine Learning Algorithms Biomarkers
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Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn's disease by bioinformatics analysis and machine learning.

Scientific reports Jan 27, 2025
Crohn's disease (CD) is a chronic inflammatory bowel disease with an unknown etiology. Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD. Differen...
Ubiquitin-Conjugating Enzymes Nedd4 Ubiquitin Protein Ligases Gene Ontology Ubiquitination Humans Machine Learning Caco-2 Cells Gene Expression Profiling Gene Regulatory Networks Macrophages Crohn Disease Protein Interaction Maps Biomarkers Computational Biology
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Point Mutation Ubiquitin-Conjugating Enzymes Cysteine Protein Multimerization Computational Biology Ubiquitin-Protein Ligases Molecular Docking Simulation Isoenzymes Models, Molecular Humans Biocatalysis Cattle Ubiquitin Iodine Radioisotopes Animals Ubiquitination Amino Acid Substitution Expert Systems Protein Conformation Binding Sites Recombinant Fusion Proteins Mutagenesis, Site-Directed
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