AIMC Topic: Ubiquitin-Conjugating Enzymes

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Identification and Validation of Glycosylation‑Related Genes in Ischemic Stroke Based on Bioinformatics and Machine Learning.

Journal of molecular neuroscience : MN Apr 29, 2025
Ischemic stroke (IS) constitutes a severe neurological disorder with restricted treatment alternatives. Recent investigations have disclosed that glycosylation is closely associated with the occurrence and outcome of IS. Nevertheless, data on the tra...
Transcriptome Gene Regulatory Networks Machine Learning Ischemic Stroke Ubiquitin-Conjugating Enzymes Glycosylation Computational Biology Humans
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Identification of UBE2N as a biomarker of Alzheimer's disease by combining WGCNA with machine learning algorithms.

Scientific reports Feb 22, 2025
Alzheimer's disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its ...
Humans Biomarkers Animals Algorithms Machine Learning Hippocampus Alzheimer Disease Ubiquitin-Conjugating Enzymes Gene Regulatory Networks Mice Gene Expression Profiling
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Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn's disease by bioinformatics analysis and machine learning.

Scientific reports Jan 27, 2025
Crohn's disease (CD) is a chronic inflammatory bowel disease with an unknown etiology. Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD. Differen...
Macrophages Machine Learning Gene Expression Profiling Biomarkers Humans Crohn Disease Caco-2 Cells Gene Regulatory Networks Computational Biology Protein Interaction Maps Gene Ontology Ubiquitination Ubiquitin-Conjugating Enzymes Nedd4 Ubiquitin Protein Ligases
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Expert Systems Biocatalysis Iodine Radioisotopes Ubiquitin-Protein Ligases Amino Acid Substitution Cysteine Protein Conformation Cattle Models, Molecular Computational Biology Animals Molecular Docking Simulation Humans Ubiquitin-Conjugating Enzymes Point Mutation Binding Sites Mutagenesis, Site-Directed Recombinant Fusion Proteins Isoenzymes Protein Multimerization Ubiquitin Ubiquitination
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