AIMC Topic: Recombinant Fusion Proteins

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A synthetic protein-level neural network in mammalian cells.

Science (New York, N.Y.) Dec 12, 2024
Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de novo-designed protein heterodimers and engineered v...
Humans Proteolysis Recombinant Fusion Proteins Protein Engineering Protein Multimerization Viral Proteases Neural Networks, Computer Protein Interaction Maps Cell Death Synthetic Biology HEK293 Cells
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Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study.

PloS one Feb 14, 2022
PURPOSE: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source o...
Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Retinal Detachment Humans Tomography, Optical Coherence Retrospective Studies Retina Adult Macular Degeneration Deep Learning Intravitreal Injections Visual Acuity Proof of Concept Study
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Characterizing the function of domain linkers in regulating the dynamics of multi-domain fusion proteins by microsecond molecular dynamics simulations and artificial intelligence.

Proteins Mar 27, 2021
Multi-domain proteins are not only formed through natural evolution but can also be generated by recombinant DNA technology. Because many fusion proteins can enhance the selectivity of cell targeting, these artificially produced molecules, called mul...
Molecular Dynamics Simulation Recombinant Fusion Proteins Computational Biology Protein Engineering Gene Expression Humans Pliability Protein Domains Mutagenesis, Insertional Artificial Intelligence Amino Acids Benchmarking
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Quantification of Key Retinal Features in Early and Late Age-Related Macular Degeneration Using Deep Learning.

American journal of ophthalmology Jan 8, 2021
PURPOSE: We sought to develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD).
Sensitivity and Specificity Male Middle Aged Deep Learning ROC Curve Humans Neural Networks, Computer Female Aged Aged, 80 and over Intravitreal Injections Recombinant Fusion Proteins Ranibizumab Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Angiogenesis Inhibitors Models, Statistical Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A Retinal Drusen Choroidal Neovascularization Geographic Atrophy
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Deep phenotype unsupervised machine learning revealed the significance of pachychoroid features in etiology and visual prognosis of age-related macular degeneration.

Scientific reports Oct 28, 2020
Unsupervised machine learning has received increased attention in clinical research because it allows researchers to identify novel and objective viewpoints for diseases with complex clinical characteristics. In this study, we applied a deep phenotyp...
Aged, 80 and over Male Angiogenesis Inhibitors Unsupervised Machine Learning Choroid Macular Degeneration Intravitreal Injections Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Choroidal Neovascularization Humans Prognosis Retrospective Studies Female Aged
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A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.

PloS one Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Middle Aged Recombinant Fusion Proteins Pilot Projects Macula Lutea Image Processing, Computer-Assisted Receptors, Vascular Endothelial Growth Factor Humans Angiogenesis Inhibitors Bevacizumab Machine Learning Treatment Outcome Retinal Vein Occlusion Female Adult Tomography, Optical Coherence Male Drug Monitoring Workflow Macular Edema Vascular Endothelial Growth Factor A
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Vascular Endothelial Growth Factors Enzyme-Linked Immunosorbent Assay Humans Prognosis Intravitreal Injections Prospective Studies Angiogenesis Inhibitors Female Recombinant Fusion Proteins Biomarkers Treatment Outcome Infant, Newborn Receptors, Vascular Endothelial Growth Factor Follow-Up Studies Male Retinopathy of Prematurity Dose-Response Relationship, Drug Time Factors
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Cytoprotective Effects of Cell-Permeable Bifunctional Antioxidant Enzyme, GST-TAT-SOD, against Cisplatin-Induced Cell Damage.

Oxidative medicine and cellular longevity Nov 30, 2017
GST-TAT-SOD, a cell-permeable bifunctional antioxidant enzyme, is a potential selective radioprotector. This study aimed to investigate the cytoprotective activity of GST-TAT-SOD against cisplatin-induced damage. The current study showed that cisplat...
Apoptosis Humans Cell Line Peptides Reactive Oxygen Species Malondialdehyde Protective Agents Superoxide Dismutase Cisplatin Glutathione Transferase Recombinant Fusion Proteins
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Expert Systems Biocatalysis Protein Conformation Cysteine Ubiquitin-Protein Ligases Amino Acid Substitution Recombinant Fusion Proteins Binding Sites Mutagenesis, Site-Directed Molecular Docking Simulation Ubiquitin Cattle Computational Biology Models, Molecular Iodine Radioisotopes Ubiquitination Humans Protein Multimerization Animals Isoenzymes Point Mutation Ubiquitin-Conjugating Enzymes
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Construction and characterization of recombinant adenovirus carrying a mouse TIGIT-GFP gene.

Genetics and molecular research : GMR Dec 29, 2015
Recombinant adenovirus vector systems have been used extensively in protein research and gene therapy. However, the construction and characterization of recombinant adenovirus is a tedious and time-consuming process. TIGIT is a recently discovered im...
Adenoviridae Genetic Vectors Hepatocytes Transduction, Genetic Receptors, Immunologic Humans Green Fluorescent Proteins Animals Gene Order Mice Recombinant Fusion Proteins Cell Line Gene Expression
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