Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
Jul 30, 2019
In this paper, the classification and location of neuroblastoma in NMR images are realized by using Deep Neural Network(CNN) algorithm as the core technology. The module is integrated to realize the development of computer-aided diagnostic software. ...
Briefings in bioinformatics
Jul 19, 2019
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by aberrations in the genome. While several disease-causing variants have been identified, a major part of heritability remains unexplained. ALS is believed to have...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Sequence-based protein-protein interaction (PPI) prediction represents a fundamental computational biology problem. To address this problem, extensive research efforts have been made to extract predefined features from the sequences. Base...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Historically, gene expression has been shown to be the most informative data for drug response prediction. Recent evidence suggests that integrating additional omics can improve the prediction accuracy which raises the question of how to ...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Alternative splicing generates multiple isoforms from a single gene, greatly increasing the functional diversity of a genome. Although gene functions have been well studied, little is known about the specific functions of isoforms, making...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Messenger RNA subcellular localization mechanisms play a crucial role in post-transcriptional gene regulation. This trafficking is mediated by trans-acting RNA-binding proteins interacting with cis-regulatory elements called zipcodes. Whi...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Neural networks have been widely used to analyze high-throughput microscopy images. However, the performance of neural networks can be significantly improved by encoding known invariance for particular tasks. Highly relevant to the goal o...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Estimating the future course of patients with cancer lesions is invaluable to physicians; however, current clinical methods fail to effectively use the vast amount of multimodal data that is available for cancer patients. To tackle this p...
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Deep learning architectures have recently demonstrated their power in predicting DNA- and RNA-binding specificity. Existing methods fall into three classes: Some are based on convolutional neural networks (CNNs), others use recurrent neur...