AIMC Topic: Nucleic Acids

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Protein-protein and protein-nucleic acid binding site prediction via interpretable hierarchical geometric deep learning.

GigaScience Jan 2, 2024
Identification of protein-protein and protein-nucleic acid binding sites provides insights into biological processes related to protein functions and technical guidance for disease diagnosis and drug design. However, accurate predictions by computati...
Humans Neural Networks, Computer COVID-19 SARS-CoV-2 Deep Learning Protein Binding Spike Glycoprotein, Coronavirus Computational Biology Nucleic Acids Binding Sites
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GeoBind: segmentation of nucleic acid binding interface on protein surface with geometric deep learning.

Nucleic acids research Jun 9, 2023
Unveiling the nucleic acid binding sites of a protein helps reveal its regulatory functions in vivo. Current methods encode protein sites from the handcrafted features of their local neighbors and recognize them via a classification, which are limite...
Algorithms Deep Learning Membrane Proteins Nucleic Acids Binding Sites
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Computational Methods and Deep Learning for Elucidating Protein Interaction Networks.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2023
Protein interactions play a critical role in all biological processes, but experimental identification of protein interactions is a time- and resource-intensive process. The advances in next-generation sequencing and multi-omics technologies have gre...
Machine Learning Deep Learning Protein Interaction Maps Computational Biology Proteins Nucleic Acids
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DeepDISOBind: accurate prediction of RNA-, DNA- and protein-binding intrinsically disordered residues with deep multi-task learning.

Briefings in bioinformatics Jan 17, 2022
Proteins with intrinsically disordered regions (IDRs) are common among eukaryotes. Many IDRs interact with nucleic acids and proteins. Annotation of these interactions is supported by computational predictors, but to date, only one tool that predicts...
Humans Neural Networks, Computer Deep Learning Protein Binding Computational Biology RNA-Binding Proteins Proteome DNA DNA-Binding Proteins RNA Intrinsically Disordered Proteins Nucleic Acids
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Mechanical Gripper Design and Force Analysis of Microplates for Automated High-Throughput Nucleic Acid Detection System.

Journal of nanoscience and nanotechnology Mar 1, 2020
In the automated high-throughput nucleic acid detection system, we need to grip and transfer consumables frequently when carrying out multichannel nucleic acid detection. In order to ensure the efficiency of experiments and solve problems of the defl...
Hand Strength Robotics Equipment Design Nucleic Acids Mechanical Phenomena
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