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Organic Cation Transport Proteins

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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire 28068143
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Adaptation, Physiological Administration, Oral Animals Carnitine O-Palmitoyltransferase Choline Diacylglycerol O-Acyltransferase fas Receptor Fatty Acids Gene Expression Regulation Glucose Insulin Receptor Substrate Proteins Insulin Resistance Lipogenesis Mice Mice, Knockout Microtubule-Associated Proteins Muscle, Skeletal Organic Cation Transport Proteins Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha PPAR alpha RNA Nucleotidyltransferases Signal Transduction Stearoyl-CoA Desaturase Sterol Regulatory Element Binding Protein 1 Triglycerides
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MATEPRED-A-SVM-Based Prediction Method for Multidrug And Toxin Extrusion (MATE) Proteins.

Computational biology and chemistry 26256800
The growth and spread of drug resistance in bacteria have been well established in both mankind and beasts and thus is a serious public health concern. Due to the increasing problem of drug resistance, control of infectious diseases like diarrhea, pn...
Amino Acids Dipeptides Drug Resistance Hydrophobic and Hydrophilic Interactions Organic Cation Transport Proteins Position-Specific Scoring Matrices Reproducibility of Results Support Vector Machine
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Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction.

Journal of biomolecular structure & dynamics 37340665
Chronic disease patients (cancer, arthritis, cardiovascular diseases) undergo long-term systemic drug treatment. Membrane transporters in ocular barriers could falsely recognize these drugs and allow their trafficking into the eye from systemic circu...
Artificial Intelligence Binding Sites Humans Ligands Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Organic Cation Transport Proteins Organic Cation Transporter 1 Protein Binding
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Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models.

Journal of chemical information and modeling 39254593
Renal secretion plays an important role in excretion of drug from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2 K and OCT2, the former of which is highly related to drug-drug interactions. Among publish...
Humans Machine Learning Models, Molecular Neural Networks, Computer Organic Cation Transport Proteins
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