AIMC Topic: Organic Cation Transport Proteins

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Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.

Journal of medicinal chemistry Jun 13, 2025
The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Tandem Mass Spectrometry HEK293 Cells Chromatography, High Pressure Liquid Organic Cation Transporter 1 Organic Cation Transporter 2 Substrate Specificity Organic Cation Transport Proteins Humans
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Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models.

Journal of chemical information and modeling Sep 10, 2024
Renal secretion plays an important role in excretion of drug from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2 K and OCT2, the former of which is highly related to drug-drug interactions. Among publish...
Machine Learning Models, Molecular Organic Cation Transport Proteins Humans Neural Networks, Computer
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Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction.

Journal of biomolecular structure & dynamics Jun 20, 2023
Chronic disease patients (cancer, arthritis, cardiovascular diseases) undergo long-term systemic drug treatment. Membrane transporters in ocular barriers could falsely recognize these drugs and allow their trafficking into the eye from systemic circu...
Molecular Docking Simulation Protein Binding Machine Learning Binding Sites Organic Cation Transport Proteins Molecular Dynamics Simulation Ligands Humans Artificial Intelligence Organic Cation Transporter 1
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Adaptation, Physiological Carnitine O-Palmitoyltransferase Signal Transduction Administration, Oral Diacylglycerol O-Acyltransferase Choline Mice Muscle, Skeletal Insulin Receptor Substrate Proteins Fatty Acids Mice, Knockout Insulin Resistance Stearoyl-CoA Desaturase Triglycerides fas Receptor Glucose Animals Lipogenesis Microtubule-Associated Proteins RNA Nucleotidyltransferases Gene Expression Regulation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Organic Cation Transport Proteins Sterol Regulatory Element Binding Protein 1 PPAR alpha
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MATEPRED-A-SVM-Based Prediction Method for Multidrug And Toxin Extrusion (MATE) Proteins.

Computational biology and chemistry Jul 29, 2015
The growth and spread of drug resistance in bacteria have been well established in both mankind and beasts and thus is a serious public health concern. Due to the increasing problem of drug resistance, control of infectious diseases like diarrhea, pn...
Organic Cation Transport Proteins Position-Specific Scoring Matrices Hydrophobic and Hydrophilic Interactions Drug Resistance Dipeptides Reproducibility of Results Support Vector Machine Amino Acids
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