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Phosphodiesterase Inhibitors

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Gaussian Process Regression Models for the Prediction of Hydrogen Bond Acceptor Strengths.

Molecular informatics
We present two approaches for the computation of hydrogen bond acceptor strengths, one by machine-learning and one by a composite quantum-mechanical protocol, both based on the well-established pK scale and dataset. The QM calculations after a necess...

Immediate post-operative PDE5i therapy improves early erectile function outcomes after robot assisted radical prostatectomy (RARP).

Journal of robotic surgery
To assess whether the timing of post-operative Phosphodiesterase Inhibitor (PDE5i) therapy after Robot-Assisted Radical Prostatectomy (RARP) is associated with a change in early erectile function (EF) outcomes, continence or safety outcomes. Data wer...