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Comparison of response surface methodology and artificial neural network to optimize novel ophthalmic flexible nano-liposomes: Characterization, evaluation, in vivo pharmacokinetics and molecular dynamics simulation.

Colloids and surfaces. B, Biointerfaces 30173096
To improve the topical delivery of pilocarpine hydrochloride (PN) to treat glaucoma, flexible nano-liposomes containing PN (PN-FLs) were prepared, optimized and characterized. Artificial neural network (ANN) and response surface methodology (RSM) wer...
Animals Drug Liberation Irritants Liposomes Molecular Dynamics Simulation Nanoparticles Neural Networks, Computer Ophthalmic Solutions Particle Size Pilocarpine Rabbits Spectroscopy, Fourier Transform Infrared Static Electricity Thermodynamics
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