AIMC Topic: Protein Structure, Secondary

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NetSurfP-3.0: accurate and fast prediction of protein structural features by protein language models and deep learning.

Nucleic acids research
Recent advances in machine learning and natural language processing have made it possible to profoundly advance our ability to accurately predict protein structures and their functions. While such improvements are significantly impacting the fields o...

SSpro/ACCpro 6: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, deep learning and structural similarity.

Bioinformatics (Oxford, England)
MOTIVATION: Accurately predicting protein secondary structure and relative solvent accessibility is important for the study of protein evolution, structure and an early-stage component of typical protein 3D structure prediction pipelines.

CoCoPRED: coiled-coil protein structural feature prediction from amino acid sequence using deep neural networks.

Bioinformatics (Oxford, England)
MOTIVATION: Coiled-coil is composed of two or more helices that are wound around each other. It widely exists in proteins and has been discovered to play a variety of critical roles in biology processes. Generally, there are three types of structural...

Predicting RNA Secondary Structure Using In Vitro and In Vivo Data.

Methods in molecular biology (Clifton, N.J.)
The new flow of high-throughput RNA secondary structure data coming from different techniques allowed the further development of machine learning approaches. We developed CROSS and CROSSalive, two algorithms trained on experimental data able to predi...

PSSP-MVIRT: peptide secondary structure prediction based on a multi-view deep learning architecture.

Briefings in bioinformatics
The prediction of peptide secondary structures is fundamentally important to reveal the functional mechanisms of peptides with potential applications as therapeutic molecules. In this study, we propose a multi-view deep learning method named Peptide ...

EMNUSS: a deep learning framework for secondary structure annotation in cryo-EM maps.

Briefings in bioinformatics
Cryo-electron microscopy (cryo-EM) has become one of important experimental methods in structure determination. However, despite the rapid growth in the number of deposited cryo-EM maps motivated by advances in microscopy instruments and image proces...

AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2.

Proceedings of the National Academy of Sciences of the United States of America
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades a human cell via human angiotensin-converting enzyme 2 (hACE2) as the entry, causing the severe coronavirus disease (COVID-19). The interactions between hACE...

A Tour of Unsupervised Deep Learning for Medical Image Analysis.

Current medical imaging
BACKGROUND: Interpretation of medical images for the diagnosis and treatment of complex diseases from high-dimensional and heterogeneous data remains a key challenge in transforming healthcare. In the last few years, both supervised and unsupervised ...

Variable Length Character N-Gram Embedding of Protein Sequences for Secondary Structure Prediction.

Protein and peptide letters
BACKGROUND: The prediction of a protein's secondary structure from its amino acid sequence is an essential step towards predicting its 3-D structure. The prediction performance improves by incorporating homologous multiple sequence alignment informat...

OPUS-TASS: a protein backbone torsion angles and secondary structure predictor based on ensemble neural networks.

Bioinformatics (Oxford, England)
MOTIVATION: Predictions of protein backbone torsion angles (ϕ and ψ) and secondary structure from sequence are crucial subproblems in protein structure prediction. With the development of deep learning approaches, their accuracies have been significa...