AIMC Topic: Receptors, Opioid, kappa

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De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.

Journal of chemical information and modeling Aug 9, 2023
Likely effective pharmacological interventions for the treatment of opioid addiction include attempts to attenuate brain reward deficits during periods of abstinence. Pharmacological blockade of the κ-opioid receptor (KOR) has been shown to abolish b...
Animals Deep Learning Rats Analgesics, Opioid Opioid-Related Disorders Narcotic Antagonists Receptors, Opioid, kappa
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Novel Big Data-Driven Machine Learning Models for Drug Discovery Application.

Molecules (Basel, Switzerland) Jan 18, 2022
Most contemporary drug discovery projects start with a 'hit discovery' phase where small chemicals are identified that have the capacity to interact, in a chemical sense, with a protein target involved in a given disease. To assist and accelerate thi...
Humans Machine Learning Algorithms Computer Simulation Drug Discovery Big Data Protein Binding Ligands Protein Conformation Receptor, Adenosine A2A Receptors, Opioid, kappa
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Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression.

Function (Oxford, England) May 19, 2025
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...
Animals Male Rats Rats, Sprague-Dawley Analgesics, Opioid Fentanyl Respiratory Insufficiency Carotid Body Receptors, Opioid, kappa
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