Having always been driven by the need to get new treatments to patients as quickly as possible, drug discovery is a constantly evolving process. This chapter will review how medicinal chemistry was established, how it has changed over the years due t...
IEEE journal of biomedical and health informatics
Jun 3, 2021
Physicians increasingly depend on electronic health records (EHRs) to manage their patients. However, many patient records have substantial missing values that pose a fundamental challenge to their clinical use. To address this prevailing challenge, ...
Computational intelligence and neuroscience
Jun 2, 2021
Ultrasound is one of the critical methods for diagnosis and treatment in thyroid examination. In clinical application, many reasons, such as large outpatient traffic, time-consuming training of sonographers, and uneven professional level of physician...
Biochimica et biophysica acta. Reviews on cancer
May 31, 2021
Pharmaceutical agents in oncology currently have high attrition rates from early to late phase clinical trials. Recent advances in computational methods, notably causal artificial intelligence, and availability of rich clinico-genomic databases have ...
BACKGROUND: Several models have been developed to predict mortality in patients with COVID-19 pneumonia, but only a few have demonstrated enough discriminatory capacity. Machine learning algorithms represent a novel approach for the data-driven predi...
AIMS: One of the major drivers of the adoption of digital pathology in clinical practice is the possibility of introducing digital image analysis (DIA) to assist with diagnostic tasks. This offers potential increases in accuracy, reproducibility, and...
Generally, in real decision-making, all the pieces of information are used to find the optimal alternatives. However, in many cases, the decision-makers (DMs) only want "how good/bad a thing can become." One possibility is to classify the alternative...
Clinical & experimental ophthalmology
May 25, 2021
Reporting guidelines are structured tools developed using explicit methodology that specify the minimum information required by researchers when reporting a study. The use of artificial intelligence (AI) reporting guidelines that address potential so...
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
May 17, 2021
Extracting clinical concepts and their relations from clinical narratives is one of the fundamental tasks in clinical natural language processing. Traditional solutions often separate this task into two subtasks with a pipeline architecture, which fi...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
May 15, 2021
Rib fractures are injuries commonly assessed in trauma wards. Deep learning has demonstrated state-of-the-art accuracy for a variety of tasks, including image classification. This paper assesses the speed-accuracy trade-offs and general suitability o...