AIMC Topic: Hemorrhagic Fever, Ebola

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Single-cell image-based screens identify host regulators of Ebola virus infection dynamics.

Nature microbiology Jul 24, 2025
Filoviruses such as Ebola virus (EBOV) give rise to frequent epidemics with high case fatality rates while therapeutic options remain limited. Earlier genetic screens aimed to identify potential drug targets for EBOV relied on systems that may not fu...
Humans Ebolavirus Animals Virus Replication Hemorrhagic Fever, Ebola Single-Cell Analysis Cell Line Viral Regulatory and Accessory Proteins RNA, Viral Host-Pathogen Interactions
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Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine.

Nature communications Jul 9, 2025
Ebola virus disease (EVD) outbreaks are increasing, posing significant threats to affected communities. Effective outbreak management depends on protecting frontline health workers, a key focus of EVD vaccination strategies. IgG specific to the viral...
Receptors, Antigen, B-Cell Plasma Cells Ebola Vaccines Machine Learning Single-Cell Analysis Humans Immunoglobulin G B-Lymphocytes Antibodies, Viral Female Ebolavirus Vaccination Hemorrhagic Fever, Ebola Immunologic Memory
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Assessing concordance between RNA-Seq and NanoString technologies in Ebola-infected nonhuman primates using machine learning.

BMC genomics Apr 10, 2025
This study evaluates the concordance between RNA sequencing (RNA-Seq) and NanoString technologies for gene expression analysis in non-human primates (NHPs) infected with Ebola virus (EBOV). A detailed comparison of both platforms revealed a strong co...
Gene Expression Profiling Dendritic Cells RNA-Seq Ebolavirus Humans Machine Learning Animals Hemorrhagic Fever, Ebola 2',5'-Oligoadenylate Synthetase
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Supervised learning approaches for predicting Ebola-Human Protein-Protein interactions.

Gene Jan 17, 2025
The goal of this research work is to predict protein-protein interactions (PPIs) between the Ebola virus and the host who is at risk of infection. Since there are very limited databases available on the Ebola virus; we have prepared a comprehensive d...
Hemorrhagic Fever, Ebola Databases, Protein Supervised Machine Learning Host-Pathogen Interactions Protein Interaction Maps Computational Biology Ebolavirus Viral Proteins Humans Support Vector Machine Gene Ontology Protein Interaction Mapping
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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.

Cell host & microbe Jan 15, 2025
Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and spec...
Filoviridae Niemann-Pick C1 Protein Filoviridae Infections Chiroptera Hemorrhagic Fever, Ebola Receptors, Virus Machine Learning Animals Phylogeny Protein Binding Glycoproteins Ebolavirus Humans
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Artificial neural network-driven modeling of Ebola transmission dynamics with delays and disability outcomes.

Computational biology and chemistry Jan 13, 2025
This study develops an Artificial Neural Network (ANN)-based framework to model the transmission dynamics and long-term disability outcomes of Ebola Virus Disease (EVD). Building on existing deterministic SEIR models, we extend the framework by intro...
Algorithms Hemorrhagic Fever, Ebola Humans Neural Networks, Computer
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Automatic face detection based on bidirectional recurrent neural network optimized by improved Ebola optimization search algorithm.

Scientific reports Nov 13, 2024
Face detection is a multidisciplinary research subject that employs fundamental computer algorithms, image processing, and patterning. Neural networks, on the other hand, have been widely developed to solve challenges in the domains of feature extrac...
Humans Neural Networks, Computer Algorithms Image Processing, Computer-Assisted Face Databases, Factual Deep Learning Pattern Recognition, Automated Hemorrhagic Fever, Ebola
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Automatic detection and classification of lung cancer CT scans based on deep learning and ebola optimization search algorithm.

PloS one Aug 17, 2023
Recently, research has shown an increased spread of non-communicable diseases such as cancer. Lung cancer diagnosis and detection has become one of the biggest obstacles in recent years. Early lung cancer diagnosis and detection would reliably promot...
Lung Neoplasms Hemorrhagic Fever, Ebola Hospitals, Teaching Algorithms Tomography, X-Ray Computed Deep Learning Humans
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Comparison of machine learning methods for estimating case fatality ratios: An Ebola outbreak simulation study.

PloS one Sep 15, 2021
BACKGROUND: Machine learning (ML) algorithms are now increasingly used in infectious disease epidemiology. Epidemiologists should understand how ML algorithms behave within the context of outbreak data where missingness of data is almost ubiquitous.
Data Interpretation, Statistical Survival Analysis Computer Simulation Hemorrhagic Fever, Ebola Datasets as Topic Humans Disease Outbreaks Machine Learning Models, Statistical Research Design
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Toward a Coronavirus Knowledge Graph.

Genes Jun 29, 2021
This study builds a coronavirus knowledge graph (KG) by merging two information sources. The first source is Analytical Graph (AG), which integrates more than 20 different public datasets related to drug discovery. The second source is CORD-19, a col...
Knowledge Bases Pattern Recognition, Automated Peptidyl-Dipeptidase A Databases, Factual SARS-CoV-2 Humans PubMed Hydroxychloroquine COVID-19 Computer Graphics STAT1 Transcription Factor Receptors, Interleukin-6 Hemorrhagic Fever, Ebola Chloroquine
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