AIMC Topic: RNA, Circular

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CircCNNs, a convolutional neural network framework to better understand the biogenesis of exonic circRNAs.

Scientific reports Aug 16, 2024
Circular RNAs (circRNAs) as biomarkers for cancer detection have been extensively explored, however, the biogenesis mechanism is still elusive. In contrast to linear splicing (LS) involved in linear transcript formation, the so-called back splicing (...
Neural Networks, Computer Machine Learning Humans Exons RNA, Circular Computational Biology RNA Splicing
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MAMLCDA: A Meta-Learning Model for Predicting circRNA-Disease Association Based on MAML Combined With CNN.

IEEE journal of biomedical and health informatics Jul 2, 2024
Circular RNAs (circRNAs) exist in vivo and are a class of noncoding RNA molecules. They have a single-stranded, closed, annular structure. Many studies have shown that circRNAs and diseases are linked. Therefore, it is critical to build a reliable an...
RNA, Circular Machine Learning Algorithms Humans Computational Biology Neural Networks, Computer Principal Component Analysis
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BiLSTM- and CNN-Based m6A Modification Prediction Model for circRNAs.

Molecules (Basel, Switzerland) May 21, 2024
m6A methylation, a ubiquitous modification on circRNAs, exerts a profound influence on RNA function, intracellular behavior, and diverse biological processes, including disease development. While prediction algorithms exist for mRNA m6A modifications...
RNA, Circular HEK293 Cells Adenosine Humans Neural Networks, Computer Algorithms Computational Biology Methylation
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KFDAE: CircRNA-Disease Associations Prediction Based on Kernel Fusion and Deep Auto-Encoder.

IEEE journal of biomedical and health informatics May 6, 2024
CircRNA has been proved to play an important role in the diseases diagnosis and treatment. Considering that the wet-lab is time-consuming and expensive, computational methods are viable alternative in these years. However, the number of circRNA-disea...
Humans Deep Learning Computational Biology Neural Networks, Computer Algorithms RNA, Circular
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CRIECNN: Ensemble convolutional neural network and advanced feature extraction methods for the precise forecasting of circRNA-RBP binding sites.

Computers in biology and medicine Apr 10, 2024
Circular RNAs (circRNAs) have surfaced as important non-coding RNA molecules in biology. Understanding interactions between circRNAs and RNA-binding proteins (RBPs) is crucial in circRNA research. Existing prediction models suffer from limited availa...
RNA, Circular Binding Sites Humans Neural Networks, Computer Computational Biology RNA-Binding Proteins
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LMGATCDA: Graph Neural Network With Labeling Trick for Predicting circRNA-Disease Associations.

IEEE/ACM transactions on computational biology and bioinformatics Apr 3, 2024
Previous studies have proven that circular RNAs (circRNAs) are inextricably connected to the etiology and pathophysiology of complicated diseases. Since conventional biological research are frequently small-scale, expensive, and time-consuming, it is...
Computational Biology RNA, Circular Neural Networks, Computer Algorithms
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Predicting circRNA-RBP Binding Sites Using a Hybrid Deep Neural Network.

Interdisciplinary sciences, computational life sciences Feb 21, 2024
Circular RNAs (circRNAs) are non-coding RNAs generated by reverse splicing. They are involved in biological process and human diseases by interacting with specific RNA-binding proteins (RBPs). Due to traditional biological experiments being costly, c...
RNA, Circular Binding Sites Humans Neural Networks, Computer Computational Biology Deep Learning RNA-Binding Proteins
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CIRI-Deep Enables Single-Cell and Spatial Transcriptomic Analysis of Circular RNAs with Deep Learning.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Feb 2, 2024
Circular RNAs (circRNAs) are a crucial yet relatively unexplored class of transcripts known for their tissue- and cell-type-specific expression patterns. Despite the advances in single-cell and spatial transcriptomics, these technologies face difficu...
Transcriptome Deep Learning RNA RNA, Circular Gene Expression Profiling
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DCDA: CircRNA-Disease Association Prediction with Feed-Forward Neural Network and Deep Autoencoder.

Interdisciplinary sciences, computational life sciences Nov 17, 2023
Circular RNA is a single-stranded RNA with a closed-loop structure. In recent years, academic research has revealed that circular RNAs play critical roles in biological processes and are related to human diseases. The discovery of potential circRNAs ...
RNA, Circular Humans Computational Biology RNA Neural Networks, Computer
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CRBSP:Prediction of CircRNA-RBP Binding Sites Based on Multimodal Intermediate Fusion.

IEEE/ACM transactions on computational biology and bioinformatics Oct 9, 2023
Circular RNA (CircRNA) is widely expressed and has physiological and pathological significance, regulating post-transcriptional processes via its protein-binding activity. However, whereas much work has been done on linear RNA and RNA binding protein...
Binding Sites Protein Binding RNA, Circular RNA Neural Networks, Computer
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