AIMC Topic: Software

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The DynaSig-ML Python package: automated learning of biomolecular dynamics-function relationships.

Bioinformatics (Oxford, England)
UNLABELLED: The DynaSig-ML ('Dynamical Signatures-Machine Learning') Python package allows the efficient, user-friendly exploration of 3D dynamics-function relationships in biomolecules, using datasets of experimental measures from large numbers of s...

Identifying B-cell epitopes using AlphaFold2 predicted structures and pretrained language model.

Bioinformatics (Oxford, England)
MOTIVATION: Identifying the B-cell epitopes is an essential step for guiding rational vaccine development and immunotherapies. Since experimental approaches are expensive and time-consuming, many computational methods have been designed to assist B-c...

A high-performance deep-learning-based pipeline for whole-brain vasculature segmentation at the capillary resolution.

Bioinformatics (Oxford, England)
MOTIVATION: Reconstructing and analyzing all blood vessels throughout the brain is significant for understanding brain function, revealing the mechanisms of brain disease, and mapping the whole-brain vascular atlas. Vessel segmentation is a fundament...

Effective and efficient active learning for deep learning-based tissue image analysis.

Bioinformatics (Oxford, England)
MOTIVATION: Deep learning attained excellent results in digital pathology recently. A challenge with its use is that high quality, representative training datasets are required to build robust models. Data annotation in the domain is labor intensive ...

ChatGPT: Chances and Challenges for Dentistry.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
The artificial intelligence (AI) chatbot ChatGPT has generated both huge interest and deep concern since its launch in November 2022.1 ChatGPT, a large language model (LLM) with a conversational interface, has been trained on vast amounts of human-ge...

A novel architecture design for artificial intelligence-assisted culture conservation management system.

Mathematical biosciences and engineering : MBE
Native culture construction has been a prevalent issue in many countries, and its integration with intelligent technologies seems promising. In this work, we take the Chinese opera as the primary research object and propose a novel architecture desig...

miWords: transformer-based composite deep learning for highly accurate discovery of pre-miRNA regions across plant genomes.

Briefings in bioinformatics
Discovering pre-microRNAs (miRNAs) is the core of miRNA discovery. Using traditional sequence/structural features, many tools have been published to discover miRNAs. However, in practical applications like genomic annotations, their actual performanc...

Deep-learning optimized DEOCSU suite provides an iterable pipeline for accurate ChIP-exo peak calling.

Briefings in bioinformatics
Recognizing binding sites of DNA-binding proteins is a key factor for elucidating transcriptional regulation in organisms. ChIP-exo enables researchers to delineate genome-wide binding landscapes of DNA-binding proteins with near single base-pair res...

DeepOM: single-molecule optical genome mapping via deep learning.

Bioinformatics (Oxford, England)
MOTIVATION: Efficient tapping into genomic information from a single microscopic image of an intact DNA molecule is an outstanding challenge and its solution will open new frontiers in molecular diagnostics. Here, a new computational method for optic...

[Fake paper factories: root cause solutions are needed.].

Recenti progressi in medicina
The pressure to publish academic papers for career advancement and technological innovations have fostered the growth of a new phenomenon, the serial fabrication of articles to be submitted to scientific journals. Papers with fake content are produce...