AIMC Topic: Synaptic Vesicles

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Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise.

Translational neurodegeneration
BACKGROUND: Atg9-containing vesicles are enriched in synapses and undergo cycles of exo- and endocytosis similarly to synaptic vesicles, thereby linking presynaptic autophagy to neuronal activity. Dysfunction of presynaptic autophagy is a pathophysio...

Mechano-fluorescence actuation in single synaptic vesicles with a DNA framework nanomachine.

Science robotics
Biomimetic machines that can convert mechanical actuation to adaptive coloration in a manner analogous to cephalopods have found widespread applications at various length scales. At the nanoscale, a transmutable nanomachine with adaptive colors that ...

Deep learning-based synapse counting and synaptic ultrastructure analysis of electron microscopy images.

Journal of neuroscience methods
BACKGROUND: Synapses are the connections between neurons in the central nervous system (CNS) or between neurons and other excitable cells in the peripheral nervous system (PNS), where electrical or chemical signals rapidly travel through one cell to ...