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TNF-Related Apoptosis-Inducing Ligand

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[Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid].

Yao xue xue bao = Acta pharmaceutica Sinica
To investigate the effects of gambognic acid (GA) on TRAIL-induced apoptosis of cancer cells, human colon HT-29 cancer cells were treated with GA to promote apoptosis. Inhibition of the cell proliferation was measured with MTT assay and cell apoptosi...

Designing combination therapies with modeling chaperoned machine learning.

PLoS computational biology
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d...