AIMC Topic: TNF-Related Apoptosis-Inducing Ligand

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Designing combination therapies with modeling chaperoned machine learning.

PLoS computational biology Sep 9, 2019
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d...
Humans Machine Learning Algorithms Neoplasms Antineoplastic Agents Computational Biology Signal Transduction Models, Biological Cisplatin Drug Therapy, Combination TNF-Related Apoptosis-Inducing Ligand Drug Therapy, Computer-Assisted
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[Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid].

Yao xue xue bao = Acta pharmaceutica Sinica Oct 1, 2015
To investigate the effects of gambognic acid (GA) on TRAIL-induced apoptosis of cancer cells, human colon HT-29 cancer cells were treated with GA to promote apoptosis. Inhibition of the cell proliferation was measured with MTT assay and cell apoptosi...
Humans Cell Line, Tumor Cell Proliferation Apoptosis Reactive Oxygen Species Colonic Neoplasms Xanthones Caspases Down-Regulation Up-Regulation HT29 Cells Apoptosis Regulatory Proteins TNF-Related Apoptosis-Inducing Ligand
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