AIMC Topic: HT29 Cells
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Discovery and Characterization of Novel Receptor-Interacting Protein Kinase 1 Inhibitors Using Deep Learning and Virtual Screening.
ACS chemical neuroscience
Apr 3, 2025
Receptor-interacting protein kinase 1 (RIPK1) serves as a critical mediator of cell necroptosis and represents a promising therapeutic target for various human neurodegenerative diseases and inflammatory diseases. Nonetheless, the RIPK1 inhibitors cu...
Identification of LPCAT1 as a key biomarker for Crohn's disease based on bioinformatics and machine learnings and experimental verification.
Gene
May 3, 2024
Epithelial-mesenchymal transition (EMT) plays a crucial role in regulating inflammatory responses and fibrosis formation. This study aims to explore the molecular mechanisms of EMT-related genes in Crohn's disease (CD) through bioinformatics methods ...
Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery.
Science robotics
Jan 19, 2022
We propose two-dimensional poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their high-speed (15 to 23 micrometer per second; 9.5 ± 5.4 body lengths per second) swimming in...
Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang).
Food chemistry
Oct 26, 2017
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidati...
Manipulation of Biomolecule-Modified Liquid-Metal Blobs.
Angewandte Chemie (International ed. in English)
Oct 2, 2017
Soft and deformable liquid metals (LMs) are building components in various systems related to uncertain and dynamic task environments. Herein we describe the development of a biomolecule-triggered external-manipulation method involving LM conjugates ...
Anticancer and anti-inflammatory activities of girinimbine isolated from .
Drug design, development and therapy
Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Apoptosis
Lipopolysaccharides
Dose-Response Relationship, Drug
Cell Survival
Structure-Activity Relationship
Anti-Inflammatory Agents, Non-Steroidal
Zebrafish
Antineoplastic Agents, Phytogenic
Drug Screening Assays, Antitumor
Animals
Mice
Nitric Oxide
Cell Proliferation
Humans
Cytokines
Alkaloids
HT29 Cells
Tumor Cells, Cultured
Murraya
Modelling with ANIMO: between fuzzy logic and differential equations.
BMC systems biology
Jul 27, 2016
BACKGROUND: Computational support is essential in order to reason on the dynamics of biological systems. We have developed the software tool ANIMO (Analysis of Networks with Interactive MOdeling) to provide such computational support and allow insigh...
Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy.
International journal of medicinal mushrooms
Jan 1, 2018
Fomitopsis pinicola (Sw.) P. Karst. (Fomitopsidaceae) is a medicinal mushroom with a variety of healthy properties. In this study we tested the radical scavenging activity and antimicrobial and anticancer potential of methanol extracts of F. pinicola...
Fruiting Bodies, Fungal
Phenols
Coriolaceae
Cell Proliferation
Picrates
Humans
Antifungal Agents
THP-1 Cells
HT29 Cells
Apoptosis
Antineoplastic Agents
Chemical Fractionation
Methanol
Biphenyl Compounds
Cell Survival
Phylogeny
Agaricales
Free Radical Scavengers
Flavonoids
Microbial Sensitivity Tests
[Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid].
Yao xue xue bao = Acta pharmaceutica Sinica
Oct 1, 2015
To investigate the effects of gambognic acid (GA) on TRAIL-induced apoptosis of cancer cells, human colon HT-29 cancer cells were treated with GA to promote apoptosis. Inhibition of the cell proliferation was measured with MTT assay and cell apoptosi...
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