AIMC Topic: Von Hippel-Lindau Tumor Suppressor Protein

Clear Filters Showing 1 to 2 of 2 articles

Predicting tumor mutation burden and VHL mutation from renal cancer pathology slides with self-supervised deep learning.

Cancer medicine Aug 1, 2024
BACKGROUND: Tumor mutation burden (TMB) and VHL mutation play a crucial role in the management of patients with clear cell renal cell carcinoma (ccRCC), such as guiding adjuvant chemotherapy and improving clinical outcomes. However, the time-consumin...
Humans Female Aged Biomarkers, Tumor Male Middle Aged Deep Learning Mutation Kidney Neoplasms Carcinoma, Renal Cell Von Hippel-Lindau Tumor Suppressor Protein
View on PubMed DOI

Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau disease.

Human molecular genetics Jan 20, 2024
BACKGROUND: Mutations within the Von Hippel-Lindau (VHL) tumor suppressor gene are known to cause VHL disease, which is characterized by the formation of cysts and tumors in multiple organs of the body, particularly clear cell renal cell carcinoma (c...
Humans Machine Learning Kidney Neoplasms Carcinoma, Renal Cell Mutation, Missense von Hippel-Lindau Disease Von Hippel-Lindau Tumor Suppressor Protein
View on PubMed DOI
Popular Topics
Recent Journals