AI Medical Compendium

Cyclosporine in hematological disorders: mechanisms, clinical practice and emerging advances.

Annals of hematology May 29, 2026

Cyclosporine A (CsA) functions as a calcineurin inhibitor that perturbs T cell activation via calcineurin-nuclear factor of activated T cells (CaN-NFAT) signaling inhibitors, establishing its central role in hematological therapeutics. This review de... read more

Exercise-related genes predicts overall survival and tumor immune microenvironment, and identifies the biological role of SLC52A2 in breast cancer.

Discover oncology May 29, 2026

BACKGROUND: Breast cancer (BRCA) is the most common malignant tumor in women, with prognoses differing markedly by molecular subtype. Exercise is known to be related to tumor occurrence and progression, yet its role in BRCA remains understudied. This... read more

New Frontiers of Drug Development Through the Use of New Approach Methodologies.

The AAPS journal May 29, 2026

On November 2025, AAPS PharmSci 360 convened a symposium that included experts in the application of various types of New Approach Methodologies (NAMs). They shared their experiences and insights on topics that included microphysiological systems (MP... read more

Integrative multi-omics, machine learning, and experimental validation reveal that TPM1 suppresses M2 macrophage polarization and enhances chemosensitivity in acute myeloid leukemia.

Cell biology and toxicology May 29, 2026

BACKGROUND: Acute myeloid leukemia (AML) remains a therapeutic challenge due to chemoresistance and immunosuppression. This study aimed to discover novel regulatory mechanisms in AML pathogenesis. METHODS: Integrative transcriptomic (GSE30029) and pr... read more

Clinical governance of artificial intelligence in internal medicine: a literature-informed five-pillar framework for complex care.

Internal and emergency medicine May 29, 2026

Most artificial intelligence (AI) governance frameworks in healthcare address model development, reporting standards, or regulation in broad terms, but do not adequately translate these principles into the operational realities of internal medicine. ... read more

RNA-centric approaches in amyotrophic lateral sclerosis: prospects for future therapeutics.

Expert opinion on therapeutic targets May 29, 2026

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by profound clinical and molecular heterogeneity, which has substantially hindered the development of effective therapies. Significant advances in A... read more

A novel prognostic model based on MVIRGs identifies ANGPT2 as a key target driving the malignant progression of HCC.

Biological procedures online May 29, 2026

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high recurrence and limited therapies. Microvascular invasion (MVI) is a critical prognostic factor, but its molecular mechanisms and precise predictive tools are lacking. ... read more

The impact of an artificial intelligence (AI)-assisted education program on mental health, social support and quality of life in older individuals with head and neck cancer: study protocol of a randomized controlled trial.

BMC geriatrics May 29, 2026

BACKGROUND: Head and neck cancer (HNC) is a common malignant tumor, and its treatment often leads to functional impairments in speech, swallowing, and appearance, severely affecting patients' quality of life. Older individuals with HNC, due to the co... read more

Beyond prediction: explainable machine learning for ferritin estimation from complete blood count.

BMC medical informatics and decision making May 29, 2026

BACKGROUND: Serum ferritin is a primary marker of body iron stores; however, its diagnostic utility is limited by cost and non-specific elevation during inflammatory states. This study aimed to develop and validate explainable machine learning (ML) m... read more

MSTM-Net: a two-stage prostate cancer segmentation network based on swin-transformer-mamba architecture.

BMC medical imaging May 29, 2026

BACKGROUND: Magnetic resonance imaging (MRI) has become a core imaging modality for prostate cancer screening and diagnosis. Accurate and automatic segmentation of lesion regions is critical for subsequent staging assessment and treatment planning. M... read more

Artificial Intelligence Medical Compendium