Combined deep learning and radiomics in pretreatment radiation esophagitis prediction for patients with esophageal cancer underwent volumetric modulated arc therapy.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PMID:

Abstract

PURPOSE: To develop a combined radiomics and deep learning (DL) model in predicting radiation esophagitis (RE) of a grade ≥ 2 for patients with esophageal cancer (EC) underwent volumetric modulated arc therapy (VMAT) based on computed tomography (CT) and radiation dose (RD) distribution images.

Authors

  • Congying Xie
    Department of Radiation and Medical Oncology, The 1st Affiliated Hospital of Wenzhou Medical University, No.2 Fuxue Lane, Wenzhou, 325000, People's Republic of China. wzxiecongying@163.com.
  • Xianwen Yu
    ByteDance Inc, Beijing, China.
  • Ninghang Tan
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Jicheng Zhang
    Department of Radiotherapy Center, 1(st) Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
  • Wanyu Su
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Weihua Ni
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Chenyu Li
    Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, College of Life Sciences, Northwest University, Xi'an 710069, China.
  • Zeshuo Zhao
    Department of Radiotherapy Center, 1(st) Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
  • Ziqing Xiang
    Department of Radiotherapy Center, 1(st) Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
  • Li Shao
    Department of Radiotherapy Center, 1(st) Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
  • Heng Li
    Department of Anesthesiology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan Province, China.
  • Jianping Wu
    Department of Civil Engineering, Tsinghua University, Beijing, 100084, China.
  • Zhuo Cao
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Juebin Jin
    Department of Medical Engineering, The 1st Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Wenzhou, 325000, People's Republic of China.
  • Xiance Jin
    Department of Radiation and Medical Oncology, The 1st Affiliated Hospital of Wenzhou Medical University, No.2 Fuxue Lane, Wenzhou, 325000, People's Republic of China.