External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study.

Journal: The Lancet. Digital health
PMID:

Abstract

BACKGROUND: The myocardial-ischaemic-injury-index (MI) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI, both when using early serial blood draws (eg, at 1 h or 2 h) and in direct comparison with guideline-recommended algorithms, remains unknown. Our aim was to externally validate MI and compare its performance with that of the European Society of Cardiology (ESC) 0/1h-algorithm.

Authors

  • Pedro Lopez-Ayala
    Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Heart Center Basel, University Hospital Basel, University of Basel, Switzerland.
  • Jasper Boeddinghaus
    Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Heart Center Basel, University Hospital Basel, University of Basel, Switzerland; BHF/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
  • Thomas Nestelberger
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Luca Koechlin
    Department of Surgery, University Hospital Basel, Basel, Switzerland.
  • Tobias Zimmermann
    Junior Research Group wearHEALTH, University of Kaiserslautern, Gottlieb-Daimler-Str. 48, 67663 Kaiserslautern, Germany. tobias.zimmermann@cs.uni-kl.de.
  • Paolo Bima
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Jonas Glaeser
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Carlos C Spagnuolo
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Arnaud Champetier
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Oscar Miro
    GREAT Association, Rome, Italy; Emergency Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.
  • Francisco Javier Martin-Sanchez
    GREAT Association, Rome, Italy; Emergency Department, Hospital ClĂ­nico San Carlos, Madrid, Spain.
  • Dagmar I Keller
    Emergency Department, Klinik Gut, St Moritz, Switzerland.
  • Michael Christ
    Department of Emergency Medicine, Luzerner Kantonsspital, Luzern, Switzerland.
  • Karin Wildi
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Tobias Breidthardt
    Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Association, Rome, Italy.
  • Ivo Strebel
    Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel and University of Basel, Petersgraben 4, 4031 Basel, Switzerland.
  • Christian Mueller
    Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Heart Center Basel, University Hospital Basel, University of Basel, Switzerland.