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Troponin I

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Effects of medium- and long-distance running on cardiac damage markers in amateur runners: a systematic review, meta-analysis, and metaregression.

Journal of sport and health science
BACKGROUND: To finish an endurance race, athletes perform a vigorous effort that induces the release of cardiac damage markers. There are several factors that can affect the total number of these markers, so the aim of this review was to analyze the ...

Ultrasensitive sandwich-type immunosensor for cardiac troponin I based on enhanced electrocatalytic reduction of HO using β-cyclodextrins functionalized 3D porous graphene-supported Pd@Au nanocubes.

Journal of materials chemistry. B
In this study, Pd@Au nanocubes supported β-cyclodextrins functionalized three-dimensional porous graphene (CDs-3D-PG-Pd@Au NCs) was synthesized using a facile method. β-cyclodextrins (CDs) were beneficial in improving the dispersibility of three-dime...

Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis.

Circulation
BACKGROUND: Heart failure (HF) risk and the underlying risk factors vary by race. Traditional models for HF risk prediction treat race as a covariate in risk prediction and do not account for significant parameters such as cardiac biomarkers. Machine...

A deep learning algorithm for detecting acute myocardial infarction.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
BACKGROUND: Delayed diagnosis or misdiagnosis of acute myocardial infarction (AMI) is not unusual in daily practice. Since a 12-lead electrocardiogram (ECG) is crucial for the detection of AMI, a systematic algorithm to strengthen ECG interpretation ...

Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury.

Scientific reports
Chest pain is a common clinical complaint for which myocardial injury is the primary concern and is associated with significant morbidity and mortality. To aid providers' decision-making, we aimed to analyze the electrocardiogram (ECG) using a deep c...

External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study.

The Lancet. Digital health
BACKGROUND: The myocardial-ischaemic-injury-index (MI) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI, both when using early serial blood draws (e...

Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study.

The Lancet. Digital health
BACKGROUND: Point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) assays have been shown to provide similar analytical precision despite substantially shorter turnaround times compared with laboratory-based hs-cTn assays. We applied the prev...

Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing.

Small (Weinheim an der Bergstrasse, Germany)
Democratizing biomarker testing at the point-of-care requires innovations that match laboratory-grade sensitivity and precision in an accessible format. Here, high-sensitivity detection of cardiac troponin I (cTnI) is demonstrated through innovations...

ZnO nanoflower-mediated paper-based electrochemical biosensor for perfect classification of cardiac biomarkers with physics-informed machine learning.

Mikrochimica acta
The widespread exposure of acute myocardial infarction globally demands an ultrasensitive, rapid, and cost-effective biosensor for troponin-I and T in a dynamic concentration range. Traditionally, the saturation of sensor response limits accurate pre...

Machine learning to risk stratify chest pain patients with non-diagnostic electrocardiogram in an Asian emergency department.

Annals of the Academy of Medicine, Singapore
INTRODUCTION: Elevated troponin, while essential for diagnosing myocardial infarction, can also be present in non-myocardial infarction conditions. The myocardial-ischaemic-injury-index (MI3) algorithm is a machine learning algorithm that considers a...