AIMC Topic: Troponin I
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Machine learning to risk stratify chest pain patients with non-diagnostic electrocardiogram in an Asian emergency department.
Annals of the Academy of Medicine, Singapore
Apr 22, 2025
INTRODUCTION: Elevated troponin, while essential for diagnosing myocardial infarction, can also be present in non-myocardial infarction conditions. The myocardial-ischaemic-injury-index (MI3) algorithm is a machine learning algorithm that considers a...
ZnO nanoflower-mediated paper-based electrochemical biosensor for perfect classification of cardiac biomarkers with physics-informed machine learning.
Mikrochimica acta
Mar 26, 2025
The widespread exposure of acute myocardial infarction globally demands an ultrasensitive, rapid, and cost-effective biosensor for troponin-I and T in a dynamic concentration range. Traditionally, the saturation of sensor response limits accurate pre...
Advancements and challenges in high-sensitivity cardiac troponin assays: diagnostic, pathophysiological, and clinical perspectives.
Clinical chemistry and laboratory medicine
Feb 7, 2025
Although significant progress has been made in recent years, some important questions remain regarding the analytical performance, pathophysiological interpretation and clinical use of cardiac troponin I (cTnI) and T (cTnT) measurements. Several rece...
Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing.
Small (Weinheim an der Bergstrasse, Germany)
Feb 5, 2025
Democratizing biomarker testing at the point-of-care requires innovations that match laboratory-grade sensitivity and precision in an accessible format. Here, high-sensitivity detection of cardiac troponin I (cTnI) is demonstrated through innovations...
Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study.
The Lancet. Digital health
Aug 29, 2024
BACKGROUND: Point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) assays have been shown to provide similar analytical precision despite substantially shorter turnaround times compared with laboratory-based hs-cTn assays. We applied the prev...
Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury.
Scientific reports
Feb 27, 2023
Chest pain is a common clinical complaint for which myocardial injury is the primary concern and is associated with significant morbidity and mortality. To aid providers' decision-making, we aimed to analyze the electrocardiogram (ECG) using a deep c...
Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis.
Circulation
Apr 13, 2021
BACKGROUND: Heart failure (HF) risk and the underlying risk factors vary by race. Traditional models for HF risk prediction treat race as a covariate in risk prediction and do not account for significant parameters such as cardiac biomarkers. Machine...
Effects of medium- and long-distance running on cardiac damage markers in amateur runners: a systematic review, meta-analysis, and metaregression.
Journal of sport and health science
Dec 27, 2019
BACKGROUND: To finish an endurance race, athletes perform a vigorous effort that induces the release of cardiac damage markers. There are several factors that can affect the total number of these markers, so the aim of this review was to analyze the ...
Prevalence and Predictability of Low-Yield Inpatient Laboratory Diagnostic Tests.
JAMA network open
Sep 4, 2019
IMPORTANCE: Laboratory testing is an important target for high-value care initiatives, constituting the highest volume of medical procedures. Prior studies have found that up to half of all inpatient laboratory tests may be medically unnecessary, but...
Middle Aged
ROC Curve
Predictive Value of Tests
Area Under Curve
Leukocyte Count
Troponin I
Aged
Humans
Clinical Laboratory Techniques
Adult
L-Lactate Dehydrogenase
Sensitivity and Specificity
Blood Urea Nitrogen
Glycated Hemoglobin
Machine Learning
Male
Hemoglobins
Retrospective Studies
Female
Hospitalization
Ultrasensitive sandwich-type immunosensor for cardiac troponin I based on enhanced electrocatalytic reduction of HO using β-cyclodextrins functionalized 3D porous graphene-supported Pd@Au nanocubes.
Journal of materials chemistry. B
Feb 6, 2019
In this study, Pd@Au nanocubes supported β-cyclodextrins functionalized three-dimensional porous graphene (CDs-3D-PG-Pd@Au NCs) was synthesized using a facile method. β-cyclodextrins (CDs) were beneficial in improving the dispersibility of three-dime...
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