Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing.

Journal: Frontiers in immunology
PMID: 39830504

Abstract

BACKGROUND: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions.

Authors

  • Yafeng Jiang
    Department of Hematology, the Second Xiangya Hospital of Central South University, Changsha, China.
  • Zhaolan Hu
    Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Roujie Huang
    Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Kaying Ho
    School of Nursing, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China.
  • Pengfei Wang
    Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Jin Kang
    Department of Rheumatology and Immunology, the Second Xiangya Hospital of Central South University, Changsha, China.

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