AIMC Topic: Anti-Citrullinated Protein Antibodies

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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing.

Frontiers in immunology Jan 3, 2025
BACKGROUND: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distincti...
Adult Synovial Membrane Biomarkers Male Anti-Citrullinated Protein Antibodies Leukocytes, Mononuclear Female Middle Aged Cellular Reprogramming Single-Cell Analysis Aged Metabolic Reprogramming Arthritis, Rheumatoid Gene Regulatory Networks Humans Sequence Analysis, RNA Macrophages
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Anti-mutated citrullinated vimentin antibodies are increased in IPF patients.

Respiratory medicine and research Dec 14, 2023
INTRO: An increased prevalence of serum anti-MCV antibody is observed in the serum of patients with idiopathic pulmonary fibrosis (IPF) but the clinical relevance of these antibodies is unknown.
Registries Vimentin Idiopathic Pulmonary Fibrosis Female Humans Autoantibodies Aged Prospective Studies Mutation Middle Aged Male Anti-Citrullinated Protein Antibodies
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Association of a Serum Protein Signature With Rheumatoid Arthritis Development.

Arthritis & rheumatology (Hoboken, N.J.) Nov 10, 2020
OBJECTIVE: The pathophysiologic events that precede the onset of rheumatoid arthritis (RA) remain incompletely understood. This study was undertaken to identify changes in the serum proteome that precede the onset of RA, with the aim of providing new...
Longitudinal Studies Young Adult Anti-Citrullinated Protein Antibodies Interleukin-1 Adult Middle Aged Tumor Necrosis Factor-alpha Humans Arthritis, Rheumatoid Male Disease Progression Female Machine Learning Proteomics Calreticulin Adolescent Rheumatoid Factor Aged Indians, North American Toll-Like Receptor 2 Asymptomatic Diseases Ficolins Lectins
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Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models.

PloS one Dec 4, 2018
OBJECTIVE: Limited evidences are available on biomarkers to recognize Systemic Lupus erythematosus (SLE) patients at risk to develop erosive arthritis. Anti-citrullinated peptide antibodies (ACPA) have been widely investigated and identified in up to...
Ultrasonography Logistic Models Anti-Citrullinated Protein Antibodies Middle Aged Cohort Studies Rheumatoid Factor Arthritis Protein Carbamylation Decision Trees Lupus Erythematosus, Systemic Autoantibodies Biomarkers Female Risk Factors Adult Cross-Sectional Studies Male Humans Machine Learning
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The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.

Journal of managed care & specialty pharmacy Jul 17, 2017
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA di...
Cost of Illness Health Expenditures Antirheumatic Agents Humans Biomarkers Middle Aged Retrospective Studies Disease Progression Electronic Health Records Arthritis, Rheumatoid Treatment Outcome Female Young Adult Anti-Citrullinated Protein Antibodies Aged Adult Biological Products Male
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