Identification and cognitive function prediction of Alzheimer's disease based on multivariate pattern analysis of hippocampal volumes.

Journal: Journal of Alzheimer's disease : JAD
PMID:

Abstract

BACKGROUND: Alzheimer's disease (AD) is strongly associated with slowly progressive hippocampal atrophy. Elucidating the relationships between local morphometric changes and disease status for early diagnosis could be aided by machine learning algorithms trained on neuroimaging datasets.

Authors

  • Ziwen Gao
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Wanqiu Zhu
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Yuqing Li
    Deep Space Exploration Research Center, 47822Harbin Institute of Technology, Harbin, China.
  • Wei Ye
    AliveX Biotech, Shanghai, China.
  • Xiao Chen
  • Shanshan Zhou
    From the Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Rd, Chaoyang District, Beijing 100029, China (Z.Z., Y.G., N.Z., H.W., R.W., L.X.); School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, China (W.Z., Z.G., H.Z.); Keya Medical Company, Shenzhen, China (X.H.); Department of Cardiology, Chinese PLA General Hospital, Beijing, China (S.Z.); Department of Radiology, The First Hospital of China Medical University, Shenyang, China (X.D.); Cardiovascular Research Centre, Royal Brompton Hospital, London, UK (G.Y.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); and Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.N.).
  • Xiaohu Li
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui, China.
  • Xiaoshu Li
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Yongqiang Yu
    College of Electronic Engineering, National University of Defense Technology, Hefei 230037, China.