Markers of endothelial damage and coagulation impairment in patients with severe sepsis resuscitated with hydroxyethyl starch 130/0.42 vs Ringer acetate.

Journal: Journal of critical care
PMID: 26810483

Abstract

PURPOSE: The Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial showed increased mortality in patients resuscitated with hydroxyethyl starch 130/0.42 (HES) vs Ringer acetate. Different effects of the fluids on the endothelium may have contributed to the observed outcome. We aimed to investigate associations between HES vs Ringer and changes in plasma biomarkers reflecting endothelial damage and coagulation impairment.

Authors

  • Rasmus Beier Müller
    Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark. Electronic address: rasmus.muller@regionh.dk.
  • Sisse Rye Ostrowski
    Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
  • Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
  • Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital-Rigshospitalet DK-2100 Copenhagen, Denmark.
  • Anders Perner
    Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
  • Pär Ingemar Johansson
    Section for Transfusion Medicine, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark; Department of Surgery, University of Texas Health Medical School, Houston, TX 77030.

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