Effect of imatinib on growth of experimental endometriosis in rats.

Journal: European journal of obstetrics, gynecology, and reproductive biology
PMID: 26773307

Abstract

OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which are widely used drugs for endometriosis, is usually not possible due to their suboptimal safety and tolerance profile. The lack of an effective, tolerable and safe treatment option for endometriosis makes animal models of experimental endometriosis necessary to study candidate drugs. The aim of this study was to investigate the efficacy of imatinib on the experimental endometriosis in a rat model.

Authors

  • Caglar Yildiz
    Department of Obstetrics and Gynecology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey. Electronic address: dr_caglaryildiz@yahoo.com.tr.
  • Turgut Kacan
    Department of Medical Oncology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.
  • Ozlem Bozoklu Akkar
    Department of Obstetrics and Gynecology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.
  • Savas Karakus
    Department of Obstetrics and Gynecology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.
  • Metin Seker
    Department of Medical Oncology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.
  • Selen Baloglu Kacan
    Department of Internal Medicine, Sivas Numune Hospital, 58140 Sivas, Turkey.
  • Hatice Ozer
    Department of Pathology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.
  • Ali Cetin
    Department of Obstetrics and Gynecology, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey.

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