AIMC Topic: Imatinib Mesylate

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A deep-learning model for predicting tyrosine kinase inhibitor response from histology in gastrointestinal stromal tumor.

The Journal of pathology Feb 14, 2025
Over 90% of gastrointestinal stromal tumors (GISTs) harbor mutations in KIT or PDGFRA that can predict response to tyrosine kinase inhibitor (TKI) therapies, as recommended by NCCN (National Comprehensive Cancer Network) guidelines. However, gene seq...
Male Middle Aged Deep Learning Treatment Outcome Mutation Humans Female Aged Pyrroles Triazines Proto-Oncogene Proteins c-kit Tyrosine Kinase Inhibitors Receptor, Platelet-Derived Growth Factor alpha Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Imatinib Mesylate Pyrazoles Protein Kinase Inhibitors
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Integration of Machine Learning and Experimental Validation to Identify Anoikis-Related Prognostic Signature for Predicting the Breast Cancer Tumor Microenvironment and Treatment Response.

Genes Nov 12, 2024
Anoikis-related genes (ANRGs) are crucial in the invasion and metastasis of breast cancer (BC). The underlying role of ANRGs in the prognosis of breast cancer patients warrants further study. The anoikis-related prognostic signature (ANRS) was gene...
Machine Learning Prognosis Female Reproducibility of Results Aged Anoikis Antineoplastic Agents Gene Expression Profiling Transcriptome Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Breast Neoplasms Tumor Microenvironment Biomarkers, Tumor Immunotherapy Middle Aged Enzyme-Linked Immunosorbent Assay Treatment Outcome Databases, Genetic Predictive Value of Tests Drug Screening Assays, Antitumor Gene Expression Blotting, Western Imatinib Mesylate Proportional Hazards Models
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Imatinib adherence prediction using machine learning approach in patients with gastrointestinal stromal tumor.

Cancer Sep 6, 2024
BACKGROUND: Nonadherence to imatinib is common in patients with gastrointestinal stromal tumor (GIST), which is associated with poor prognosis and financial burden. The primary aim of this study was to investigate the adherence rate in patients with ...
Aged Adult Male Middle Aged Antineoplastic Agents Humans Machine Learning Algorithms Female Deep Learning Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Imatinib Mesylate Assessment of Medication Adherence
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Interpretable artificial intelligence to optimise use of imatinib after resection in patients with localised gastrointestinal stromal tumours: an observational cohort study.

The Lancet. Oncology Jul 5, 2024
BACKGROUND: Current guidelines recommend use of adjuvant imatinib therapy for many patients with gastrointestinal stromal tumours (GISTs); however, its optimal treatment duration is unknown and some patient groups do not benefit from the therapy. We ...
Middle Aged Antineoplastic Agents Cohort Studies Treatment Outcome Gastrointestinal Neoplasms Neoplasm Recurrence, Local Artificial Intelligence Gastrointestinal Stromal Tumors Female Imatinib Mesylate Humans Aged Chemotherapy, Adjuvant Adult Male
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Relative Factors Analysis of Imatinib Trough Concentration in Chinese Patients with Gastrointestinal Stromal Tumor.

Chemotherapy Mar 5, 2019
AIMS: Imatinib plasma trough levels (IM Cmin) have been reported to have a considerable clinical impact in patients with gastrointestinal stromal tumors (GISTs). We therefore have investigated the factors affecting IM plasma concentration in Chinese ...
Humans Asian People Female Dose-Response Relationship, Drug Aged Antigens, CD34 Adult Sex Factors Aged, 80 and over Body Weight Gastrointestinal Stromal Tumors Male Gastrectomy Imatinib Mesylate Middle Aged Body Surface Area Antineoplastic Agents China
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Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 30, 2018
Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug...
Drug Contamination Solvents Capecitabine Imatinib Mesylate Reproducibility of Results Mutagens Limit of Detection Alkanesulfonates Tandem Mass Spectrometry Gas Chromatography-Mass Spectrometry Solubility
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Anastrozole bcl-2-Associated X Protein Peritoneal Diseases Rats Endometriosis Proto-Oncogene Proteins c-kit Cell Proliferation Vascular Endothelial Growth Factor A Angiogenesis Inhibitors Peritoneum Triazoles Endometrium Female Imatinib Mesylate Transplantation, Autologous Disease Models, Animal Nitriles Animals Aromatase Inhibitors Ovarian Follicle
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Imatinib Increases Serum Creatinine by Inhibiting Its Tubular Secretion in a Reversible Fashion in Chronic Myeloid Leukemia.

Clinical lymphoma, myeloma & leukemia Dec 20, 2015
BACKGROUND: Monitoring renal function is important in imatinib-treated patients with chronic myeloid leukemia because serum creatinine may increase during the course of therapy. The mechanism of this increase and its reversibility on treatment cessat...
Antineoplastic Agents Case-Control Studies Treatment Outcome Glomerular Filtration Rate Kidney Function Tests Creatinine Drug Substitution Imatinib Mesylate Protein Kinase Inhibitors Aged Young Adult Adult Male Middle Aged Humans Retrospective Studies Female Kidney Tubules Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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[Rectal Gastrointestinal Stromal Tumor(GIST)Excised by Two Teams Following Neoadjuvant Chemotherapy-A Case Report].

Gan to kagaku ryoho. Cancer & chemotherapy Dec 1, 2019
A 67-year-old man presented with bloody stools. Colonoscopy showed a small submucosal tumor in the lower rectum. As the tumor was small, follow-up was chosen. Although he was instructed to undergo reexamination 1 year later, he did not comply. Four y...
Neoadjuvant Therapy Humans Rectum Aged Rectal Neoplasms Male Antineoplastic Agents Gastrointestinal Stromal Tumors Imatinib Mesylate
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